Ν-(5-(2-amino-4-οxο-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxypyridin-3-y)propane-2-sulfonamide

Base Information

Chemical Name:Ν-(5-(2-amino-4-οxο-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxypyridin-3-y)propane-2-sulfonamide
CAS No.:1383988-11-1
Molecular Formula:C₂₃H₂₃N₅O₄S
Molecular Weight:465.533
Hs Code.:

Synonyms:Ν-(5-(2-amino-4-οxο-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxypyridin-3-y)propane-2-sulfonamide

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Chemical Property of Ν-(5-(2-amino-4-οxο-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxypyridin-3-y)propane-2-sulfonamide

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Technology Process of Ν-(5-(2-amino-4-οxο-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxypyridin-3-y)propane-2-sulfonamide

There total 9 articles about Ν-(5-(2-amino-4-οxο-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxypyridin-3-y)propane-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.12%

: 10147-37-2
Isopropylsulfonyl chloride

: 1383987-90-3
2-amino-6-(5-amino-6-methoxypyridin-3-yl)-3-phenylquinazolin-4(3H)-one

: 1383988-11-1
Ν-(5-(2-amino-4-οxο-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxypyridin-3-y)propane-2-sulfonamide

Guidance literature:: With pyridine; at 20 ℃; for 24h;

Reference yield:

: 893440-50-1
2-(methyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinamine

: 1383988-11-1
Ν-(5-(2-amino-4-οxο-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxypyridin-3-y)propane-2-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1 h / 65 °C / Inert atmosphere

2: pyridine / 24 h / 20 °C

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In tetrahydrofuran; water;
DOI:10.1021/jm400781h

Reference yield:

: 223704-97-0
2-amino-6-iodo-3-phenylquinazolin-4(3H)-one

: 1383988-11-1
Ν-(5-(2-amino-4-οxο-3-phenyl-3,4-dihydroquinazolin-6-yl)-2-methoxypyridin-3-y)propane-2-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1 h / 65 °C / Inert atmosphere

2: pyridine / 24 h / 20 °C

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In tetrahydrofuran; water;
DOI:10.1021/jm400781h