Technology Process of C12H18O2
There total 4 articles about C12H18O2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide;
In
diethyl ether;
at -78 - 0 ℃;
for 3.25h;
- Guidance literature:
-
With
D-glucose; nicotinamide adenine dinucleotide phosphate; Ras-ADH from Ralstonia sp. DSM 6428; calcium chloride;
In
2-methyltetrahydrofuran; aq. phosphate buffer;
at 37 ℃;
for 20h;
pH=7.5;
Overall yield = 1.49 g; enantioselective reaction;
Enzymatic reaction;
DOI:10.1002/anie.202103406
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1,4-diaza-bicyclo[2.2.2]octane; benzoic acid / 64 h / 45 °C / Schlenk technique; Inert atmosphere
2: nicotinamide adenine dinucleotide phosphate; ene reductase from Bacillus subtilis (EC: 1.6.99.1); glucose dehydrogenase; D-glucose / aq. phosphate buffer; 2-methyltetrahydrofuran / 6 h / 37 °C / pH 7 / Enzymatic reaction
3: nicotinamide adenine dinucleotide phosphate; D-glucose; Ras-ADH from Ralstonia sp. DSM 6428; calcium chloride / aq. phosphate buffer; 2-methyltetrahydrofuran / 20 h / 37 °C / pH 7.5 / Enzymatic reaction
With
glucose dehydrogenase; 1,4-diaza-bicyclo[2.2.2]octane; D-glucose; nicotinamide adenine dinucleotide phosphate; ene reductase from Bacillus subtilis (EC: 1.6.99.1); Ras-ADH from Ralstonia sp. DSM 6428; benzoic acid; calcium chloride;
In
2-methyltetrahydrofuran; aq. phosphate buffer;
DOI:10.1002/anie.202103406
