N-tert-butyloxycarbonyl-α-amino-γ-bromobutyric acid methyl ester

Base Information

• Chemical Name: N-tert-butyloxycarbonyl-α-amino-γ-bromobutyric acid methyl ester
• CAS No.: 168077-38-1
• Molecular Formula: C₁₀H₁₈BrNO₄
• Molecular Weight: 296.161
• Mol file: 168077-38-1.mol

Synonyms:N-tert-butyloxycarbonyl-α-amino-γ-bromobutyric acid methyl ester

Chemical Property of N-tert-butyloxycarbonyl-α-amino-γ-bromobutyric acid methyl ester

Chemical Property:

Purity/Quality:

98.5% ^*data from raw suppliers

2-(Boc-amino)-4-bromobutyricacidmethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butyloxycarbonyl-α-amino-γ-bromobutyric acid methyl ester

There total 2 articles about N-tert-butyloxycarbonyl-α-amino-γ-bromobutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

di-tert-butyl dicarbonate (24424-99-5) + methyl α-amino-γ-bromobutyrate hydrochloride (82636-35-9) → N-tert-butyloxycarbonyl-α-amino-γ-bromobutyric acid methyl ester (168077-38-1)

Guidance literature:

di-tert-butyl dicarbonate; methyl α-amino-γ-bromobutyrate hydrochloride; With sodium hydrogencarbonate; In 1,4-dioxane; water; at 0 - 20 ℃;

With 1-amino-3-(dimethylamino)propane; In 1,4-dioxane; water; for 0.333333h;

Reference yield: 20.0%

methyl 2-(tert-butoxycarbonylamino)-4-hydroxy-butanoate (120042-12-8,258351-86-9) → N-tert-butyloxycarbonyl-α-amino-γ-bromobutyric acid methyl ester (168077-38-1)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 90.0%

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) + N-tert-butyloxycarbonyl-α-amino-γ-bromobutyric acid methyl ester (168077-38-1) → 1,2-bis[3-(methoxycarbonyl)-3-(tert-butoxycarbonylamino)propyloxy]benzene

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 16h; Inert atmosphere;

DOI:10.1002/ejoc.201501077

upstream raw materials:

di-tert-butyl dicarbonate

methyl α-amino-γ-bromobutyrate hydrochloride

methyl 2-(tert-butoxycarbonylamino)-4-hydroxy-butanoate

Downstream raw materials:

4-[4-(4-Benzyloxycarbonylaminobutyl)phenoxy]-2-tert-butoxycarbonylamino-butyric acid methyl ester

Boc-(3-cyano)homophenylalanine-OMe

2-[(tert-butoxycarbonyl)amino]-4-(3-cyanophenyl)butanoic acid

C₂₂H₃₁N₃O₃