(2S,3S)-1-(tert-butoxycarbonyl)-3-[3-(1,3-dioxolan-2-ylmethyl)-4-methoxyphenoxy]proline

Base Information

• Chemical Name: (2S,3S)-1-(tert-butoxycarbonyl)-3-[3-(1,3-dioxolan-2-ylmethyl)-4-methoxyphenoxy]proline
• CAS No.: 1185762-17-7
• Molecular Formula: C₂₁H₂₉NO₈
• Molecular Weight: 423.463
• Mol file: 1185762-17-7.mol

Synonyms:(2S,3S)-1-(tert-butoxycarbonyl)-3-[3-(1,3-dioxolan-2-ylmethyl)-4-methoxyphenoxy]proline

Chemical Property of (2S,3S)-1-(tert-butoxycarbonyl)-3-[3-(1,3-dioxolan-2-ylmethyl)-4-methoxyphenoxy]proline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (2S,3S)-1-(tert-butoxycarbonyl)-3-[3-(1,3-dioxolan-2-ylmethyl)-4-methoxyphenoxy]proline

There total 1 articles about (2S,3S)-1-(tert-butoxycarbonyl)-3-[3-(1,3-dioxolan-2-ylmethyl)-4-methoxyphenoxy]proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,3S)-1-(tert-butoxycarbonyl)-2-formyl-3-[3-(1,3-dioxolan-2-ylmethyl)-4-methoxyphenoxy]pyrrolidine (1185762-21-3) → (2S,3S)-1-(tert-butoxycarbonyl)-3-[3-(1,3-dioxolan-2-ylmethyl)-4-methoxyphenoxy]proline (1185762-17-7)

Guidance literature:

With sodium chlorite; 2-methyl-but-2-ene; sodium dihydrogen phosphate dihydrate; water; In tetrahydrofuran; tert-butyl alcohol; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/ejoc.200900122

Reference yield: 78.0%

L-isoleucinamide acetic acid salt + (2S,3S)-1-(tert-butoxycarbonyl)-3-[3-(1,3-dioxolan-2-ylmethyl)-4-methoxyphenoxy]proline (1185762-17-7) → {(2S,3S)-1-(tert-butoxycarbonyl)-3-[3-(1,3-dioxolan-2-ylmethyl)-4-methoxyphenoxy]prolyl}isoleucinamide (1185762-18-8)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/ejoc.200900122

upstream raw materials:

(2S,3S)-1-(tert-butoxycarbonyl)-2-formyl-3-[3-(1,3-dioxolan-2-ylmethyl)-4-methoxyphenoxy]pyrrolidine

Downstream raw materials:

{(2S,3S)-1-(tert-butoxycarbonyl)-3-[3-(1,3-dioxolan-2-ylmethyl)-4-methoxyphenoxy]prolyl}isoleucinamide