syn-(4S,2'S,3'R)-3-(2'-azido-3'-hydroxy-3'-phenyl-propionyl)-4-(1-methylethyl)-2-oxazolidinone

Base Information

Chemical Name:syn-(4S,2'S,3'R)-3-(2'-azido-3'-hydroxy-3'-phenyl-propionyl)-4-(1-methylethyl)-2-oxazolidinone
CAS No.:151003-65-5
Molecular Formula:C₁₅H₁₈N₄O₄
Molecular Weight:318.332
Hs Code.:

Synonyms:syn-(4S,2'S,3'R)-3-(2'-azido-3'-hydroxy-3'-phenyl-propionyl)-4-(1-methylethyl)-2-oxazolidinone

Suppliers and Price of syn-(4S,2'S,3'R)-3-(2'-azido-3'-hydroxy-3'-phenyl-propionyl)-4-(1-methylethyl)-2-oxazolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of syn-(4S,2'S,3'R)-3-(2'-azido-3'-hydroxy-3'-phenyl-propionyl)-4-(1-methylethyl)-2-oxazolidinone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of syn-(4S,2'S,3'R)-3-(2'-azido-3'-hydroxy-3'-phenyl-propionyl)-4-(1-methylethyl)-2-oxazolidinone

There total 5 articles about syn-(4S,2'S,3'R)-3-(2'-azido-3'-hydroxy-3'-phenyl-propionyl)-4-(1-methylethyl)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 127181-72-0
anti-(4S,2'S,3'S)-3-(3'-Hydroxy-3'-phenyl-2'-bromo-1'-oxopropyl)-4-(1-methylethyl)-2-oxazolidinone

: 151003-65-5
syn-(4S,2'S,3'R)-3-(2'-azido-3'-hydroxy-3'-phenyl-propionyl)-4-(1-methylethyl)-2-oxazolidinone

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 25 ℃; for 6h;
DOI:10.1016/j.tet.2006.07.014

Reference yield:

: 127181-71-9
anti-(4S,2'R,3'R)-3-(3'-Hydroxy-3'-phenyl-2'-bromo-1'-oxopropyl)-4-(1-methylethyl)-2-oxazolidinone

: 151003-65-5
syn-(4S,2'S,3'R)-3-(2'-azido-3'-hydroxy-3'-phenyl-propionyl)-4-(1-methylethyl)-2-oxazolidinone

Guidance literature:: With sodium azide; In dimethyl sulfoxide;
DOI:10.1021/jo00071a020

Reference yield:

: 93617-86-8
(4S)-(+)-3-bromoacetyl-4-(1-methylethyl)-2-oxazolidinone

: 151003-65-5
syn-(4S,2'S,3'R)-3-(2'-azido-3'-hydroxy-3'-phenyl-propionyl)-4-(1-methylethyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Et₂BOTf, diisopropylethylamine / 1.) CH₂Cl₂, -10 deg C to 15-20 deg C, 30 min; -73 deg C, 30 min, 2.) -73 deg C, 1.5 h; -40 deg C

2: NaN₃ / dimethylsulfoxide

With sodium azide; N-ethyl-N,N-diisopropylamine; diethylboron trifluoromethanesulfonate; In dimethyl sulfoxide;
DOI:10.1021/jo00071a020