N-(Boc)-4',5'-dimethoxy-2'-thiocyanatophenethylamine

Base Information

• Chemical Name: N-(Boc)-4',5'-dimethoxy-2'-thiocyanatophenethylamine
• CAS No.: 163276-43-5
• Molecular Formula: C₁₆H₂₂N₂O₄S
• Molecular Weight: 338.428
• Mol file: 163276-43-5.mol

Synonyms:N-(Boc)-4',5'-dimethoxy-2'-thiocyanatophenethylamine

Chemical Property of N-(Boc)-4',5'-dimethoxy-2'-thiocyanatophenethylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(Boc)-4',5'-dimethoxy-2'-thiocyanatophenethylamine

There total 4 articles about N-(Boc)-4',5'-dimethoxy-2'-thiocyanatophenethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → N-(Boc)-4',5'-dimethoxy-2'-thiocyanatophenethylamine (163276-43-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / TEA / dimethylformamide / 2 h / 60 °C

2: acetic acid / 4 h / 25 °C

With TEA; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/ja00132a033

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → N-(Boc)-4',5'-dimethoxy-2'-thiocyanatophenethylamine (163276-43-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / TEA / dimethylformamide / 2 h / 60 °C

2: acetic acid / 4 h / 25 °C

With TEA; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/ja00132a033

Reference yield:

tert-butyl N-[2-(3,4-dimethoxyphenyl)ethyl]carbamate (98062-25-0) + 1-thiocyanatopyrrolidine-2,5-dione (163276-49-1) → N-(Boc)-4',5'-dimethoxy-2'-thiocyanatophenethylamine (163276-43-5)

Guidance literature:

In acetic acid; at 25 ℃; for 4h;

DOI:10.1021/ja00132a033

upstream raw materials:

tert-butyl N-[2-(3,4-dimethoxyphenyl)ethyl]carbamate

1-thiocyanatopyrrolidine-2,5-dione

di-tert-butyl dicarbonate

2-(3,4-dimethoxyphenyl)-ethylamine

Downstream raw materials:

[2-(2-tert-Butylsulfanyl-4,5-dimethoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester