(3aR,7R,7aR)-7-(benzoyloxy)-7,7a-dihydro-2,2-dimethyl-1,3-benzodioxol-4(3aH)-one

Base Information

Chemical Name:(3aR,7R,7aR)-7-(benzoyloxy)-7,7a-dihydro-2,2-dimethyl-1,3-benzodioxol-4(3aH)-one
CAS No.:371155-77-0
Molecular Formula:C₁₆H₁₆O₅
Molecular Weight:288.3
Hs Code.:

Synonyms:(3aR,7R,7aR)-7-(benzoyloxy)-7,7a-dihydro-2,2-dimethyl-1,3-benzodioxol-4(3aH)-one

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Chemical Property of (3aR,7R,7aR)-7-(benzoyloxy)-7,7a-dihydro-2,2-dimethyl-1,3-benzodioxol-4(3aH)-one

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Technology Process of (3aR,7R,7aR)-7-(benzoyloxy)-7,7a-dihydro-2,2-dimethyl-1,3-benzodioxol-4(3aH)-one

There total 9 articles about (3aR,7R,7aR)-7-(benzoyloxy)-7,7a-dihydro-2,2-dimethyl-1,3-benzodioxol-4(3aH)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 371155-75-8
(3aR,4R,7R,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-1,3-benzodioxole-4,7-diol 4-monobenzoate

: 371155-77-0
(3aR,7R,7aR)-7-(benzoyloxy)-7,7a-dihydro-2,2-dimethyl-1,3-benzodioxol-4(3aH)-one

Guidance literature:: With pyridine-SO₃ complex; triethylamine; In dimethyl sulfoxide; at 20 ℃; for 3h;
DOI:10.1021/jo016237a

Reference yield:

: (3aRS,4RS,7RS,7aSR)-3a,4,7,7a-tetrahydro-2,2-dimethyl-1,3-benzodioxole-4,7-diol diacetate

: 371155-77-0
(3aR,7R,7aR)-7-(benzoyloxy)-7,7a-dihydro-2,2-dimethyl-1,3-benzodioxol-4(3aH)-one

Guidance literature:: Multi-step reaction with 4 steps

1: lipase from C_. rugosa; sodium phosphate buffer; aq. NaOH / 3 h / 20 °C / pH 7.0

2: NaOMe / methanol

3: pyridine / 0 - 10 °C

4: SO₃*pyridine; Et₃N / dimethylsulfoxide / 3 h / 20 °C

With sodium hydroxide; pyridine-SO₃ complex; sodium phosphate buffer; lipase from C_. rugosa; sodium methylate; triethylamine; In pyridine; methanol; dimethyl sulfoxide;
DOI:10.1021/jo016237a

Reference yield:

: 438034-27-6
(3aS,4R,7R,7aR)-3a,4,7,7a-tetrahydro-2,2-dimethyl-1,3-benzodioxole-4,7-diol 4-monoacetate

: 371155-77-0
(3aR,7R,7aR)-7-(benzoyloxy)-7,7a-dihydro-2,2-dimethyl-1,3-benzodioxol-4(3aH)-one

Guidance literature:: Multi-step reaction with 3 steps

1: NaOMe / methanol

2: pyridine / 0 - 10 °C

3: SO₃*pyridine; Et₃N / dimethylsulfoxide / 3 h / 20 °C

With pyridine-SO₃ complex; sodium methylate; triethylamine; In pyridine; methanol; dimethyl sulfoxide;
DOI:10.1021/jo016237a