alpha-amino-3-(hydroxy)-5-methyl-4-isoxazoleacetic acid

Base Information

Chemical Name:alpha-amino-3-(hydroxy)-5-methyl-4-isoxazoleacetic acid
CAS No.:77006-27-0
Molecular Formula:C₆H₈N₂O₄
Molecular Weight:172.141
Hs Code.:2934999090
Mol file:77006-27-0.mol

Synonyms:alpha-amino-3-(hydroxy)-5-methyl-4-isoxazoleacetic acid

Suppliers and Price of alpha-amino-3-(hydroxy)-5-methyl-4-isoxazoleacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of alpha-amino-3-(hydroxy)-5-methyl-4-isoxazoleacetic acid

Chemical Property:

Vapor Pressure:5.73E-08mmHg at 25°C
Boiling Point:424.6°C at 760 mmHg
Flash Point:210.6°C
PSA：109.58000
Density:1.49g/cm³
LogP:0.47330

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of alpha-amino-3-(hydroxy)-5-methyl-4-isoxazoleacetic acid

There total 11 articles about alpha-amino-3-(hydroxy)-5-methyl-4-isoxazoleacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: ethyl (R,S)-2-amino-2-(3-methoxy-5-methyl-4-isoxazolyl)acetate hydrobromide

: 77006-27-0
2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid

Guidance literature:: With hydrogen bromide; for 0.5h; Heating;
DOI:10.1021/jm950393q

Reference yield: 47.0%

: 183282-35-1
ethyl (R,S)-2--2-(3-methoxy-5-methyl-4-isoxazolyl)acetate

: 77006-27-0
2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid

Guidance literature:: With hydrogen bromide; for 1h; Heating;
DOI:10.1002/(SICI)1099-1344(199610)38:10<915::AID-JLCR903>3.0.CO;2-B

Reference yield:

: 183282-36-2
ethyl (R,S)-2--2-<5-(bromomethyl)-3-methoxy-4-isoxazolyl>acetate

: 77006-27-0
2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / H₂ / 5percent Pd/C / ethanol / 1 h

2: 47 percent / 48percent aq. HBr / 1 h / Heating

With hydrogen bromide; hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1002/(SICI)1099-1344(199610)38:10<915::AID-JLCR903>3.0.CO;2-B