N²-isobutyryl-5'-O-monomethoxytrityl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate)

Base Information

• Chemical Name: N²-isobutyryl-5'-O-monomethoxytrityl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate)
• CAS No.: 115222-29-2
• Molecular Formula: C₅₈H₅₇N₈O₁₅P
• Molecular Weight: 1137.11

Synonyms:N²-isobutyryl-5'-O-monomethoxytrityl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate)

Chemical Property of N²-isobutyryl-5'-O-monomethoxytrityl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate)

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Technology Process of N²-isobutyryl-5'-O-monomethoxytrityl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate)

There total 2 articles about N²-isobutyryl-5'-O-monomethoxytrityl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

bis<2-(p-nitrophenyl)ethyl> phosphorochloridate (85363-77-5) + N2-isobutyryl5'-O-monomethoxytrityl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine (91592-86-8) → N2-isobutyryl-5'-O-monomethoxytrityl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate) (115222-29-2)

Guidance literature:

With pyridine; 1-methyl-1H-imidazole; for 4h; Ambient temperature;

DOI:10.1002/hlca.19870700508

Reference yield:

bis(p-nitrophenylethyl)phosphite (85363-76-4) → N2-isobutyryl-5'-O-monomethoxytrityl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate) (115222-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / SO₂Cl₂ / CCl₄; CH₂Cl₂ / 0.25 h

2: 91 percent / pyridine, N-methylimidazole / 4 h / Ambient temperature

With pyridine; 1-methyl-1H-imidazole; sulfuryl dichloride; In tetrachloromethane; dichloromethane;

DOI:10.1002/hlca.19870700508

Reference yield: 82.0%

N2-isobutyryl-5'-O-monomethoxytrityl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate) (115222-29-2) → N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1002/hlca.19870700508

upstream raw materials:

bis<2-(p-nitrophenyl)ethyl> phosphorochloridate

N²-isobutyryl5'-O-monomethoxytrityl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine

bis(p-nitrophenylethyl)phosphite

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