ethyl 7-(4-((N-(4-bromophenyl)carbamoyloxy)methyl)imidazolyl)-3-ethoxy-6-nitroquinoxaline-2-carboxylate

Base Information

Chemical Name:ethyl 7-(4-((N-(4-bromophenyl)carbamoyloxy)methyl)imidazolyl)-3-ethoxy-6-nitroquinoxaline-2-carboxylate
CAS No.:221164-30-3
Molecular Formula:C₂₄H₂₁BrN₆O₇
Molecular Weight:585.371
Hs Code.:

Synonyms:ethyl 7-(4-((N-(4-bromophenyl)carbamoyloxy)methyl)imidazolyl)-3-ethoxy-6-nitroquinoxaline-2-carboxylate

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Chemical Property of ethyl 7-(4-((N-(4-bromophenyl)carbamoyloxy)methyl)imidazolyl)-3-ethoxy-6-nitroquinoxaline-2-carboxylate

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Technology Process of ethyl 7-(4-((N-(4-bromophenyl)carbamoyloxy)methyl)imidazolyl)-3-ethoxy-6-nitroquinoxaline-2-carboxylate

There total 8 articles about ethyl 7-(4-((N-(4-bromophenyl)carbamoyloxy)methyl)imidazolyl)-3-ethoxy-6-nitroquinoxaline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 2493-02-9
4-bromophenyl isocyanate

: 221164-29-0
ethyl 3-ethoxy-7-[4-(hydroxymethyl)imidazol-1-yl]-6-nitroquinoxaline-2-carboxylate

: 221164-30-3
ethyl 7-(4-((N-(4-bromophenyl)carbamoyloxy)methyl)imidazolyl)-3-ethoxy-6-nitroquinoxaline-2-carboxylate

Guidance literature:: In dichloromethane; at 20 ℃; for 3h;

Reference yield: 52.0%

: 221164-29-0
ethyl 3-ethoxy-7-[4-(hydroxymethyl)imidazol-1-yl]-6-nitroquinoxaline-2-carboxylate

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 221164-30-3
ethyl 7-(4-((N-(4-bromophenyl)carbamoyloxy)methyl)imidazolyl)-3-ethoxy-6-nitroquinoxaline-2-carboxylate

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In benzene; for 3h; Heating / reflux;

Reference yield:

: 364-78-3
2-nitro-4-fluoroaniline

: 221164-30-3
ethyl 7-(4-((N-(4-bromophenyl)carbamoyloxy)methyl)imidazolyl)-3-ethoxy-6-nitroquinoxaline-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / toluene / 24 h / Heating

2: 31 percent / potassium tert-butoxide / dimethylformamide / 1.5 h / 0 °C

3: 75 percent / PBr₃ / dimethylformamide / 1.5 h / 20 °C

4: 45 percent / AcOH; HNO₃ / 2 h / 80 °C

5: 68 percent / silver(I) oxide / toluene / 2 h / 100 °C

6: 43 percent / triethylamine / acetonitrile / 16 h / Heating

7: CH₂Cl₂ / 8 h / 20 °C

With potassium tert-butylate; nitric acid; phosphorus tribromide; acetic acid; triethylamine; silver(l) oxide; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmc.2005.05.030