1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-(2-tert-butyldiphenylsilyloxyethyl)-1H,3H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-(2-tert-butyldiphenylsilyloxyethyl)-1H,3H-pyrimidine-2,4-dione
• CAS No.: 914381-98-9
• Molecular Formula: C₂₇H₃₄N₂O₆Si
• Molecular Weight: 510.662

Synonyms:1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-(2-tert-butyldiphenylsilyloxyethyl)-1H,3H-pyrimidine-2,4-dione

Chemical Property of 1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-(2-tert-butyldiphenylsilyloxyethyl)-1H,3H-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

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Technology Process of 1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-(2-tert-butyldiphenylsilyloxyethyl)-1H,3H-pyrimidine-2,4-dione

There total 1 articles about 1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-(2-tert-butyldiphenylsilyloxyethyl)-1H,3H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-5-(2-tert-butyldiphenylsilyloxyethyl)-1H,3H-pyrimidine-2,4-dione (914381-97-8) → 1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-(2-tert-butyldiphenylsilyloxyethyl)-1H,3H-pyrimidine-2,4-dione (914381-98-9)

Guidance literature:

1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-5-(2-tert-butyldiphenylsilyloxyethyl)-1H,3H-pyrimidine-2,4-dione; With methanol; sodium methylate; at 20 ℃; for 2h;

With acetic acid; In methanol;

DOI:10.1080/15257770903307276

Reference yield: 98.0%

1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-(2-tert-butyldiphenylsilyloxyethyl)-1H,3H-pyrimidine-2,4-dione (914381-98-9) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-(2-tert-butyldiphenylsilyloxyethyl)-1H,3H-pyrimidine-2,4-dione (914381-99-0)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1080/15257770903307276

Reference yield: 64.4%

1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-(2-tert-butyldiphenylsilyloxyethyl)-1H,3H-pyrimidine-2,4-dione (914381-98-9) + tert-butylchlorodiphenylsilane (58479-61-1) → 1-[(2-deoxy-β-D-erythro-pentofuranosyl)-5-(tert-butyldiphenylsilyl)]-5-(tert-butyldiphenylsilyloxyethyl)-1H,3H-pyrimidin-2,4-dione (1338780-34-9)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2011.08.007

upstream raw materials:

1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-5-(2-tert-butyldiphenylsilyloxyethyl)-1H,3H-pyrimidine-2,4-dione

Downstream raw materials:

1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-(2-tert-butyldiphenylsilyloxyethyl)-1H,3H-pyrimidine-2,4-dione

1-[(2-deoxy-β-D-erythro-pentofuranosyl)-5-(tert-butyldiphenylsilyl)]-5-(tert-butyldiphenylsilyloxyethyl)-1H,3H-pyrimidin-2,4-dione

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