6-hydroxy-2-(3-aminophenyl)-3-iodo-1-methyl-1H-indole-5-carboxylic acid

Base Information

Chemical Name:6-hydroxy-2-(3-aminophenyl)-3-iodo-1-methyl-1H-indole-5-carboxylic acid
CAS No.:1492896-47-5
Molecular Formula:C₁₆H₁₃IN₂O₃
Molecular Weight:408.195
Hs Code.:

Synonyms:6-hydroxy-2-(3-aminophenyl)-3-iodo-1-methyl-1H-indole-5-carboxylic acid

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Chemical Property of 6-hydroxy-2-(3-aminophenyl)-3-iodo-1-methyl-1H-indole-5-carboxylic acid

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Technology Process of 6-hydroxy-2-(3-aminophenyl)-3-iodo-1-methyl-1H-indole-5-carboxylic acid

There total 12 articles about 6-hydroxy-2-(3-aminophenyl)-3-iodo-1-methyl-1H-indole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

: 1492896-32-8
methyl 6-hydroxy-2-(3-aminophenyl)-3-iodo-1-methyl-1H-indole-5-carboxylate

: 1492896-47-5
6-hydroxy-2-(3-aminophenyl)-3-iodo-1-methyl-1H-indole-5-carboxylic acid

Guidance literature:: methyl 6-hydroxy-2-(3-aminophenyl)-3-iodo-1-methyl-1H-indole-5-carboxylate; With lithium hydroxide; In tetrahydrofuran; at 80 ℃; for 2h;

With hydrogenchloride; In water; under 5 Torr;
DOI:10.1021/jm5006176

Reference yield:

: C₂₁H₂₁IN₂O₅

: 1492896-47-5
6-hydroxy-2-(3-aminophenyl)-3-iodo-1-methyl-1H-indole-5-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1089/ars.2013.5463

Reference yield:

: 1143579-89-8
methyl 4-(dimethylamino)-2-hydroxy-5-iodobenzoate

: 1492896-47-5
6-hydroxy-2-(3-aminophenyl)-3-iodo-1-methyl-1H-indole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: iodine / dichloromethane / 4 h / 20 °C

3: sodium hydroxide / tetrahydrofuran; methanol / 48 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;
DOI:10.1002/cmdc.201300115