Gallopamil

Base Information

• Chemical Name: Gallopamil
• CAS No.: 16662-47-8
• Molecular Formula: C28H40 N2 O5
• Molecular Weight: 521.097
• UNII: 39WPC8JHR8
• DSSTox Substance ID: DTXSID5045172
• Nikkaji Number: J13.326D
• Wikipedia: Gallopamil
• Wikidata: Q412127
• NCI Thesaurus Code: C83725
• Pharos Ligand ID: 5U3NGQGRZBVP
• Metabolomics Workbench ID: 67412
• ChEMBL ID: CHEMBL51149
• Mol file: 16662-47-8.mol

Synonyms:D 600;D-600;D600;Elgiprona;Gallobeta;Gallopamil;Gallopamil Hydrochloride;gallopamil von ct;Hydrochloride, Gallopamil;Methoxyverapamil;Prebet;Procorum

Chemical Property of Gallopamil

Chemical Property:

• Vapor Pressure: 1.25E-14mmHg at 25°C
• Refractive Index: nD25 1.5402
• Boiling Point: 605.9°Cat760mmHg
• PKA: 8.96±0.50(Predicted)
• Flash Point: 320.2°C
• PSA: 73.18000
• Density: 1.068g/cm³
• LogP: 5.66408
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 14
• Exact Mass: 484.29372238
• Heavy Atom Count: 35
• Complexity: 639

Purity/Quality:

98%,99%, ^*data from raw suppliers

(+/-)-Methoxyverapamil ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C(=C2)OC)OC)OC
• Recent ClinicalTrials: Effects of Gallopamil in Severe Asthma
• Uses: (±)-Methoxyverapamil hydrochloride has been used: as calcium channel antagonist in Schistosoma mansoni parasiteas calcium entry blocker in cultured macrophagesin the inhibition of L-type voltage gated Ca2+-channels

Technology Process of Gallopamil

There total 2 articles about Gallopamil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methylhomoveratrylamine (3490-06-0) + α-(2-formylethyl)-α-isopropyl-3,4,5-trimethoxybenzeneacetonitrile (66332-86-3) → d,l-4-cyano-1-[N-methyl-N-(2'-{3'',4''-dimethoxyphenyl}-ethyl)-amino]-5-methyl-4-(3',4',5'-trimethoxyphenyl)-hexane hydrochloride (16662-47-8,16662-46-7,56949-75-8)

Guidance literature:

In formic acid;

Reference yield:

→ gallopamil (16662-47-8)

Guidance literature:

entspr. γ-Oxopropylacetonitril 2b, N-Methyl-homoveratrylamin;

upstream raw materials:

N-methylhomoveratrylamine

α-(2-formylethyl)-α-isopropyl-3,4,5-trimethoxybenzeneacetonitrile

Refernces

• 1、 -. "ANTIHYPERTENSIVE THERAPY". . . Retrieved 2009/09/08.
• 2、 -. "Preparation of phenylacetonitriles carrying basic substituents". . . Retrieved 2008/06/13.