2-(2-hydroxy-3-phenylphenyl)-8-(2-hydroxy-3,5-di-tert-butylphenyl)quinoline

Base Information

Chemical Name:2-(2-hydroxy-3-phenylphenyl)-8-(2-hydroxy-3,5-di-tert-butylphenyl)quinoline
CAS No.:1431846-99-9
Molecular Formula:C₃₅H₃₅NO₂
Molecular Weight:501.668
Hs Code.:

Synonyms:2-(2-hydroxy-3-phenylphenyl)-8-(2-hydroxy-3,5-di-tert-butylphenyl)quinoline

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Chemical Property of 2-(2-hydroxy-3-phenylphenyl)-8-(2-hydroxy-3,5-di-tert-butylphenyl)quinoline

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Technology Process of 2-(2-hydroxy-3-phenylphenyl)-8-(2-hydroxy-3,5-di-tert-butylphenyl)quinoline

There total 4 articles about 2-(2-hydroxy-3-phenylphenyl)-8-(2-hydroxy-3,5-di-tert-butylphenyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1431846-98-8
8-bromo-2-[2-(methoxymethoxy)[1,1'-biphenyl]-3-yl]quinoline

: 264259-04-3
2,4-di-tert-butylphenyl methoxymethyl ether

: 1431846-99-9
2-(2-hydroxy-3-phenylphenyl)-8-(2-hydroxy-3,5-di-tert-butylphenyl)quinoline

Guidance literature:: 8-bromo-2-[2-(methoxymethoxy)[1,1'-biphenyl]-3-yl]quinoline; 2,4-di-tert-butylphenyl methoxymethyl ether; With n-butyllithium; tris-(o-tolyl)phosphine; zinc(II) chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; hexane; at 20 ℃;

With hydrogenchloride; In ethanol; water; for 2h; Heating;
DOI:10.1021/om4001555

Reference yield:

: 90-43-7,287950-96-3
2-Phenylphenol

: 1431846-99-9
2-(2-hydroxy-3-phenylphenyl)-8-(2-hydroxy-3,5-di-tert-butylphenyl)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 2 h

2.1: zinc(II) chloride; n-butyllithium; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / tetrahydrofuran; hexane / 20 °C

3.1: zinc(II) chloride; n-butyllithium; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / tetrahydrofuran; hexane / 20 °C

3.2: 2 h / Heating

With n-butyllithium; sodium hydride; triphenylphosphine; tris-(o-tolyl)phosphine; zinc(II) chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; hexane; 2.1: |Negishi Coupling / 3.1: |Negishi Coupling;
DOI:10.1021/om4001555

Reference yield:

: 96-76-4
2,4-di-tert-Butylphenol

: 1431846-99-9
2-(2-hydroxy-3-phenylphenyl)-8-(2-hydroxy-3,5-di-tert-butylphenyl)quinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 3 h

2.1: zinc(II) chloride; n-butyllithium; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / tetrahydrofuran; hexane / 20 °C

2.2: 2 h / Heating

With n-butyllithium; sodium hydride; tris-(o-tolyl)phosphine; zinc(II) chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; hexane; 2.1: |Negishi Coupling;
DOI:10.1021/om4001555