Technology Process of (3S,3aS,4S,5S,7S,7aS)-7-iodo-4,5-di-(4-methoxybenzyl)oxy-3-methyl-3a,4,5,6,7,7a-hexahydrobenzofuran-2(3H)-one
There total 13 articles about (3S,3aS,4S,5S,7S,7aS)-7-iodo-4,5-di-(4-methoxybenzyl)oxy-3-methyl-3a,4,5,6,7,7a-hexahydrobenzofuran-2(3H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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210764-99-1
(3S,3aS,4S,5S,7S,7aS)-7-iodo-4,5-di-(4-methoxybenzyl)oxy-3-methyl-3a,4,5,6,7,7a-hexahydrobenzofuran-2(3H)-one
- Guidance literature:
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With
iodine; sodium hydrogencarbonate; potassium iodide;
In
tetrahydrofuran;
for 2h;
Ambient temperature;
DOI:10.1016/S0040-4020(99)00004-6
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210764-99-1
(3S,3aS,4S,5S,7S,7aS)-7-iodo-4,5-di-(4-methoxybenzyl)oxy-3-methyl-3a,4,5,6,7,7a-hexahydrobenzofuran-2(3H)-one
- Guidance literature:
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Multi-step reaction with 9 steps
1: 90 percent / CeCl3*7H2O, NaBH4 / methanol / 0.25 h / 0 °C
2: 90 percent / PPTS / CH2Cl2 / 24 h / Ambient temperature
3: 87 percent / NaOMe / methanol / 15 h / Ambient temperature
4: 1.) NaH, imidazole / 1.) THF, 0 deg C, 40 min, 2.) 0 deg C, 1.5 h, 3.) 0 deg C, 30 min
5: 71 percent / AIBN, n-Bu3SnH / toluene / 15 h / Heating
6: 96 percent / PPTS / ethanol / 3 h / 50 °C
7: 74 percent / propionic acid / 2 h / 140 °C
8: 205 mg / t-BuOK / dimethylsulfoxide / 0.42 h / Ambient temperature
9: 87 percent / aq. NaHCO3, KI, I2 / tetrahydrofuran / 2 h / Ambient temperature
With
1H-imidazole; sodium tetrahydroborate; cerium(III) chloride; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; iodine; tri-n-butyl-tin hydride; sodium methylate; pyridinium p-toluenesulfonate; sodium hydride; sodium hydrogencarbonate; propionic acid; potassium iodide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1016/S0040-4020(99)00004-6
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210764-99-1
(3S,3aS,4S,5S,7S,7aS)-7-iodo-4,5-di-(4-methoxybenzyl)oxy-3-methyl-3a,4,5,6,7,7a-hexahydrobenzofuran-2(3H)-one
- Guidance literature:
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Multi-step reaction with 3 steps
1: 74 percent / propionic acid / 2 h / 140 °C
2: 205 mg / t-BuOK / dimethylsulfoxide / 0.42 h / Ambient temperature
3: 87 percent / aq. NaHCO3, KI, I2 / tetrahydrofuran / 2 h / Ambient temperature
With
potassium tert-butylate; iodine; sodium hydrogencarbonate; propionic acid; potassium iodide;
In
tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(99)00004-6
