Methyl-{3-[7-(tetrahydro-pyran-2-yloxy)-heptyl]-phenyl}-carbamic acid methyl ester

Base Information

• Chemical Name: Methyl-{3-[7-(tetrahydro-pyran-2-yloxy)-heptyl]-phenyl}-carbamic acid methyl ester
• CAS No.: 101639-93-4
• Molecular Formula: C₂₁H₃₃NO₄
• Molecular Weight: 363.497
• Mol file: 101639-93-4.mol

Synonyms:Methyl-{3-[7-(tetrahydro-pyran-2-yloxy)-heptyl]-phenyl}-carbamic acid methyl ester

Chemical Property of Methyl-{3-[7-(tetrahydro-pyran-2-yloxy)-heptyl]-phenyl}-carbamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl-{3-[7-(tetrahydro-pyran-2-yloxy)-heptyl]-phenyl}-carbamic acid methyl ester

There total 7 articles about Methyl-{3-[7-(tetrahydro-pyran-2-yloxy)-heptyl]-phenyl}-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyl-{3-[(Z)-7-(tetrahydro-pyran-2-yloxy)-hept-1-enyl]-phenyl}-carbamic acid methyl ester (101639-91-2,101639-92-3) → Methyl-{3-[7-(tetrahydro-pyran-2-yloxy)-heptyl]-phenyl}-carbamic acid methyl ester (101639-93-4)

Guidance literature:

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; under 760 Torr; Yield given;

DOI:10.1016/S0040-4020(01)96704-3

Reference yield:

6-(tetrahydropyrane-2-yloxy)hexan-1-al (33803-62-2) → Methyl-{3-[7-(tetrahydro-pyran-2-yloxy)-heptyl]-phenyl}-carbamic acid methyl ester (101639-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) t-BuOK / 1) THF, 0 deg C, 30 min, 2) THF, 0 deg C, 4 h

2: H₂, NaHCO₃ / 10percent Pd/C / methanol / 760 Torr

With potassium tert-butylate; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol;

DOI:10.1016/S0040-4020(01)96704-3

Reference yield:

Methyl N-methyl-N-(3-methylphenyl)carbamate (101639-89-8) → Methyl-{3-[7-(tetrahydro-pyran-2-yloxy)-heptyl]-phenyl}-carbamic acid methyl ester (101639-93-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 26.8 g / NBS, AIBN / CCl₄ / 3 h / Heating

2: 34 g / toluene / 36 h / Heating

3: 1) t-BuOK / 1) THF, 0 deg C, 30 min, 2) THF, 0 deg C, 4 h

4: H₂, NaHCO₃ / 10percent Pd/C / methanol / 760 Torr

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; tetrachloromethane; toluene;

DOI:10.1016/S0040-4020(01)96704-3

upstream raw materials:

Methyl-{3-[(Z)-7-(tetrahydro-pyran-2-yloxy)-hept-1-enyl]-phenyl}-carbamic acid methyl ester

6-(tetrahydropyrane-2-yloxy)hexan-1-al

Methyl N-methyl-N-(3-methylphenyl)carbamate

α-bromo-N-carbomethoxy-N-methyl-m-toluidine

Downstream raw materials:

Methyl-{3-[7-(tetrahydro-pyran-2-yloxy)-heptyl]-phenyl}-amine

Methanesulfonic acid 7-[3-(methyl-oct-7-enoyl-amino)-phenyl]-heptyl ester

Oct-7-enoic acid methyl-{3-[7-(tetrahydro-pyran-2-yloxy)-heptyl]-phenyl}-amide