2-[(E)-Benzyloxyimino]-3-[4-(5-{2-[(E)-benzyloxyimino]-2-methoxycarbonyl-ethyl}-2-hydroxy-phenoxy)-3-bromo-phenyl]-propionic acid

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Chemical Name:2-[(E)-Benzyloxyimino]-3-[4-(5-{2-[(E)-benzyloxyimino]-2-methoxycarbonyl-ethyl}-2-hydroxy-phenoxy)-3-bromo-phenyl]-propionic acid
CAS No.:845784-13-6
Molecular Formula:C₃₃H₂₉BrN₂O₈
Molecular Weight:661.506
Hs Code.:

Synonyms:2-[(E)-Benzyloxyimino]-3-[4-(5-{2-[(E)-benzyloxyimino]-2-methoxycarbonyl-ethyl}-2-hydroxy-phenoxy)-3-bromo-phenyl]-propionic acid

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Chemical Property of 2-[(E)-Benzyloxyimino]-3-[4-(5-{2-[(E)-benzyloxyimino]-2-methoxycarbonyl-ethyl}-2-hydroxy-phenoxy)-3-bromo-phenyl]-propionic acid

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Technology Process of 2-[(E)-Benzyloxyimino]-3-[4-(5-{2-[(E)-benzyloxyimino]-2-methoxycarbonyl-ethyl}-2-hydroxy-phenoxy)-3-bromo-phenyl]-propionic acid

There total 15 articles about 2-[(E)-Benzyloxyimino]-3-[4-(5-{2-[(E)-benzyloxyimino]-2-methoxycarbonyl-ethyl}-2-hydroxy-phenoxy)-3-bromo-phenyl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 845784-14-7
3-[4-(2-Benzyloxy-5-{2-[(E)-benzyloxyimino]-2-methoxycarbonyl-ethyl}-phenoxy)-3-bromo-phenyl]-2-[(E)-benzyloxyimino]-propionic acid

: 845784-13-6
2-[(E)-Benzyloxyimino]-3-[4-(5-{2-[(E)-benzyloxyimino]-2-methoxycarbonyl-ethyl}-2-hydroxy-phenoxy)-3-bromo-phenyl]-propionic acid

Guidance literature:: With pentamethylbenzene,; trifluoroacetic acid; at 0 - 20 ℃; for 2.5h;
DOI:10.1002/chem.200400904

Reference yield: 94.0%

: 845784-12-5
3-[4-(2-Benzyloxy-5-{2-[(E)-benzyloxyimino]-2-methoxycarbonyl-ethyl}-phenoxy)-3-bromo-phenyl]-2-[(Z)-benzyloxyimino]-propionic acid

: 845784-13-6
2-[(E)-Benzyloxyimino]-3-[4-(5-{2-[(E)-benzyloxyimino]-2-methoxycarbonyl-ethyl}-2-hydroxy-phenoxy)-3-bromo-phenyl]-propionic acid

Guidance literature:: With pentamethylbenzene,; trifluoroacetic acid; at 0 - 20 ℃; for 2.5h;
DOI:10.1002/chem.200400904

Reference yield:

: 705932-29-2
4-benzyloxy-3-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-benzaldehyde

: 845784-13-6
2-[(E)-Benzyloxyimino]-3-[4-(5-{2-[(E)-benzyloxyimino]-2-methoxycarbonyl-ethyl}-2-hydroxy-phenoxy)-3-bromo-phenyl]-propionic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: 99 percent / piperidine; Ac₂O / tetrahydrofuran / 24 h / 80 °C

2.1: 86 percent / NaBH₄ / methanol; acetonitrile / 4 h / 0 - 20 °C

3.1: 88 percent / NaOMe; BuONO / methanol / 48 h / 0 °C

4.1: imidazole; K₂CO₃ / dimethylformamide / 0.5 h / 0 °C

4.2: 91 percent / dimethylformamide / 12 h / 0 - 20 °C

5.1: 99 percent / aq. HCl / tetrahydrofuran / 20 °C

6.1: 88 percent / imidazole / dimethylformamide / 11 h / 0 - 20 °C

7.1: TEMPO; KBr; aq. NaOCl / NaHCO₃ / CH₂Cl₂ / 1 h / 0 °C

8.1: pyridine / ethanol / 20 °C

9.1: 24 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

10.1: 97 percent / TEMPO; aq. KBr; NaOCl / NaHCO₃ / acetonitrile / 2 h / 0 °C

11.1: 94 percent / TFA; pentamethylbenzene / 2.5 h / 0 - 20 °C

With piperidine; pyridine; 1H-imidazole; hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium tetrahydroborate; n-Butyl nitrite; pentamethylbenzene,; tetrabutyl ammonium fluoride; sodium methylate; acetic anhydride; potassium carbonate; trifluoroacetic acid; potassium bromide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1.1: Knoevenagel condensation;
DOI:10.1002/chem.200400904