{(R)-2-Methyl-1-[2-oxo-2-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-ethyl]-propyl}-carbamic acid benzyl ester

Base Information

• Chemical Name: {(R)-2-Methyl-1-[2-oxo-2-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-ethyl]-propyl}-carbamic acid benzyl ester
• CAS No.: 271600-14-7
• Molecular Formula: C₂₇H₄₃NO₄Si
• Molecular Weight: 473.728
• Mol file: 271600-14-7.mol

Synonyms:{(R)-2-Methyl-1-[2-oxo-2-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-ethyl]-propyl}-carbamic acid benzyl ester

Chemical Property of {(R)-2-Methyl-1-[2-oxo-2-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-ethyl]-propyl}-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of {(R)-2-Methyl-1-[2-oxo-2-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-ethyl]-propyl}-carbamic acid benzyl ester

There total 1 articles about {(R)-2-Methyl-1-[2-oxo-2-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-ethyl]-propyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

benzyl N-<1-((p-methylphenyl)sulfonyl)-2-methypropyl>carbamate (147169-18-4) + (1R)-2-endo-acetyl-2-exo-(trimethylsilyloxy)-1,7,7-trimethylbicyclo[2.2.1]heptane (204577-67-3) → {(R)-2-Methyl-1-[2-oxo-2-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-ethyl]-propyl}-carbamic acid benzyl ester (271600-14-7)

Guidance literature:

(1R)-2-endo-acetyl-2-exo-(trimethylsilyloxy)-1,7,7-trimethylbicyclo[2.2.1]heptane; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

benzyl N-<1-((p-methylphenyl)sulfonyl)-2-methypropyl>carbamate; In tetrahydrofuran; at -78 ℃; for 0.25h;

DOI:10.1002/(SICI)1521-3773(20000317)39:6<1063::AID-ANIE1063>3.0.CO;2-Y

Reference yield: 86.0%

{(R)-2-Methyl-1-[2-oxo-2-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-ethyl]-propyl}-carbamic acid benzyl ester (271600-14-7) → (R)-3-<(benzyoxycarbonyl)amino>-4-methylpentanoic acid (215608-32-5)

Guidance literature:

With ammonium cerium(IV) nitrate; In acetonitrile; at 0 ℃; for 16h;

DOI:10.1002/(SICI)1521-3773(20000317)39:6<1063::AID-ANIE1063>3.0.CO;2-Y

upstream raw materials:

benzyl N-<1-((p-methylphenyl)sulfonyl)-2-methypropyl>carbamate

(1R)-2-endo-acetyl-2-exo-(trimethylsilyloxy)-1,7,7-trimethylbicyclo[2.2.1]heptane

Downstream raw materials:

(R)-3-<(benzyoxycarbonyl)amino>-4-methylpentanoic acid