Technology Process of (2R,3S)-N-diphenylphosphinoyl-3-isopropyl-2-vinylaziridine
There total 7 articles about (2R,3S)-N-diphenylphosphinoyl-3-isopropyl-2-vinylaziridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
DOI:10.1021/jo9810157
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 90 percent / Et3N
2.1: oxalyl chloride; DMSO; N,N-diisopropylethylamine / hexane; CHCl3 / 1 h / -78 - 0 °C
3.1: ZnCl2 / tetrahydrofuran / 0.17 h / -78 °C
3.2: 6.63 g / tetrahydrofuran / 2 h / -78 °C
4.1: trifluoroacetic acid / 1 h / 0 - 20 °C
5.1: 129 mg / Et3N / dimethylformamide / 14 h / 0 °C
6.1: 77 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; zinc(II) chloride; diethylazodicarboxylate;
In
tetrahydrofuran; hexane; chloroform; N,N-dimethyl-formamide;
1.1: Acylation / 2.1: Swern oxidation / 3.1: transmetallation / 3.2: Addition / 4.1: deprotection / 5.1: Substitution / 6.1: Cyclization;
DOI:10.1021/jo9810157
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: ZnCl2 / tetrahydrofuran / 0.17 h / -78 °C
1.2: 6.63 g / tetrahydrofuran / 2 h / -78 °C
2.1: trifluoroacetic acid / 1 h / 0 - 20 °C
3.1: 129 mg / Et3N / dimethylformamide / 14 h / 0 °C
4.1: 77 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C
With
triethylamine; triphenylphosphine; trifluoroacetic acid; zinc(II) chloride; diethylazodicarboxylate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
1.1: transmetallation / 1.2: Addition / 2.1: deprotection / 3.1: Substitution / 4.1: Cyclization;
DOI:10.1021/jo9810157
