tert-butyl (S)-2-((2-amino-5-bromophenyl)aminoformyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (S)-2-((2-amino-5-bromophenyl)aminoformyl)pyrrolidine-1-carboxylate
CAS No.:1228553-73-8
Molecular Formula:C₁₆H₂₂BrN₃O₃
Molecular Weight:384.273
Hs Code.:

Synonyms:tert-butyl (S)-2-((2-amino-5-bromophenyl)aminoformyl)pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (S)-2-((2-amino-5-bromophenyl)aminoformyl)pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (S)-2-((2-amino-5-bromophenyl)aminoformyl)pyrrolidine-1-carboxylate

There total 2 articles about tert-butyl (S)-2-((2-amino-5-bromophenyl)aminoformyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1228553-73-8
tert-butyl (S)-2-((2-amino-5-bromophenyl)aminoformyl)pyrrolidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 2.58333h;

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1228553-73-8
tert-butyl (S)-2-((2-amino-5-bromophenyl)aminoformyl)pyrrolidine-1-carboxylate

: 1228553-72-7
(2S)-1-tert-butoxycarbonyl-2-(2-amino-4-bromophenylaminoacyl)pyrrolidine

Guidance literature:: 1-(tert-butoxycarbonyl)-L-proline; With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 20 ℃; for 0.166667h;

4-Bromo-benzene-1,2-diamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1228553-73-8
tert-butyl (S)-2-((2-amino-5-bromophenyl)aminoformyl)pyrrolidine-1-carboxylate

: 1613055-20-1
C₄₅H₅₂N₆O₄

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 40 °C / Inert atmosphere; Sealed tube

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere; Sealed tube

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 4 h / 90 °C / Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; acetic acid; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;