N-benzyl-N-methylthiophene-2-carboxamide

Base Information

Chemical Name:N-benzyl-N-methylthiophene-2-carboxamide
CAS No.:349404-48-4
Molecular Formula:C₁₃H₁₃NOS
Molecular Weight:231.318
Hs Code.:
DSSTox Substance ID:DTXSID80349944
Nikkaji Number:J3.624.004K
Wikidata:Q82125549

Synonyms:N-benzyl-N-methylthiophene-2-carboxamide;5245-93-2;TimTec1_002898;SCHEMBL16597337;DTXSID80349944;HMS1542D16;AKOS003243735;N-Benzyl-N-methyl-2-thiophenecarboxamide;J3.624.004K;BRD-K14216061-001-01-5;Z27745633

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-benzyl-N-methylthiophene-2-carboxamide

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:231.07178521
Heavy Atom Count:16
Complexity:238

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(CC1=CC=CC=C1)C(=O)C2=CC=CS2

Technology Process of N-benzyl-N-methylthiophene-2-carboxamide

There total 4 articles about N-benzyl-N-methylthiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 5380-42-7
thiophene-2-carboxylic acid methyl ester

: 103-67-3
benzyl-methyl-amine

: 349404-48-4
N-benzyl-N-methylthiophene-2-carboxamide

Guidance literature:: thiophene-2-carboxylic acid methyl ester; With potassium phosphate; 2,2,2-trifluoroethanol; In 1,4-dioxane; at 125 ℃; for 0.5h; Sealed tube; Schlenk technique; Inert atmosphere;

benzyl-methyl-amine; In 1,4-dioxane; at 125 ℃; for 22h; Sealed tube; Schlenk technique; Inert atmosphere;
DOI:10.1039/c7ob00593h

Reference yield:

: 100-46-9
benzylamine

: 349404-48-4
N-benzyl-N-methylthiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

1.2: Inert atmosphere

1.3: 72 h / 45 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

3.1: 2,2,2-trifluoroethanol; potassium phosphate / 1,4-dioxane / 0.5 h / 125 °C / Sealed tube; Schlenk technique; Inert atmosphere

3.2: 22 h / 125 °C / Sealed tube; Schlenk technique; Inert atmosphere

With potassium phosphate; 2,2,2-trifluoroethanol; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1039/c7ob00593h

Reference yield:

: 81616-14-0
tert-butyl N-benzyl-N-methylcarbamate

: 349404-48-4
N-benzyl-N-methylthiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

2.1: 2,2,2-trifluoroethanol; potassium phosphate / 1,4-dioxane / 0.5 h / 125 °C / Sealed tube; Schlenk technique; Inert atmosphere

2.2: 22 h / 125 °C / Sealed tube; Schlenk technique; Inert atmosphere

With potassium phosphate; 2,2,2-trifluoroethanol; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1039/c7ob00593h