4-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]butanamide trifluoroacetate

Base Information

Chemical Name:4-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]butanamide trifluoroacetate
CAS No.:1345982-67-3
Molecular Formula:C₂HF₃O₂*C₂₆H₃₆N₂O₄S
Molecular Weight:586.673
Hs Code.:

Synonyms:4-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]butanamide trifluoroacetate

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Chemical Property of 4-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]butanamide trifluoroacetate

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Technology Process of 4-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]butanamide trifluoroacetate

There total 9 articles about 4-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]butanamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1345983-58-5
4-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]butanenitrile

: 76-05-1
trifluoroacetic acid

: 1345982-67-3
4-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]butanamide trifluoroacetate

Guidance literature:: 4-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]butanenitrile; With dihydrogen peroxide; potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 2h; Cooling with ice;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: (3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7,8-dimethoxy-5-phenyl-1-4-benzothiazepine-1,1-dioxide

: 1345982-67-3
4-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]butanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride; aluminum (III) chloride / 1,2-dichloro-ethane / 2.5 h / 20 °C

1.2: Cooling with ice

2.1: pyridine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere

3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 120 °C / sealed tube

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

5.2: pH 1 - 2

6.1: borane-THF / tetrahydrofuran / 20 °C

6.2: 0.5 h

7.1: triethylamine / dichloromethane / 20 °C / Cooling with ice

8.1: dimethyl sulfoxide / 60 °C

9.1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 2 h / 20 °C / Cooling with ice

With pyridine; hydrogenchloride; aluminum (III) chloride; borane-THF; water; hydrogen; dihydrogen peroxide; potassium carbonate; triethylamine; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: (3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-5-phenyl-1,4-benzothiazepine-8-ol 1,1-dioxide

: 1345982-67-3
4-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]butanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 120 °C / sealed tube

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

4.2: pH 1 - 2

5.1: borane-THF / tetrahydrofuran / 20 °C

5.2: 0.5 h

6.1: triethylamine / dichloromethane / 20 °C / Cooling with ice

7.1: dimethyl sulfoxide / 60 °C

8.1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 2 h / 20 °C / Cooling with ice

With pyridine; borane-THF; water; hydrogen; dihydrogen peroxide; potassium carbonate; triethylamine; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;