methyl [5-chloro-2-(1,2,3,6-tetrahydropyridin-4-yl)phenyl]acetate hydrochloride

Base Information

• Chemical Name: methyl [5-chloro-2-(1,2,3,6-tetrahydropyridin-4-yl)phenyl]acetate hydrochloride
• CAS No.: 455957-78-5
• Molecular Formula: C₁₄H₁₆ClNO₂*ClH
• Molecular Weight: 302.2

Synonyms:methyl [5-chloro-2-(1,2,3,6-tetrahydropyridin-4-yl)phenyl]acetate hydrochloride

Chemical Property of methyl [5-chloro-2-(1,2,3,6-tetrahydropyridin-4-yl)phenyl]acetate hydrochloride

Chemical Property:

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Technology Process of methyl [5-chloro-2-(1,2,3,6-tetrahydropyridin-4-yl)phenyl]acetate hydrochloride

There total 1 articles about methyl [5-chloro-2-(1,2,3,6-tetrahydropyridin-4-yl)phenyl]acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-[4-chloro-2-(2-methoxy-2-oxoethyl)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate (455957-77-4) → methyl [5-chloro-2-(1,2,3,6-tetrahydropyridin-4-yl)phenyl]acetate hydrochloride (455957-78-5)

Guidance literature:

With hydrogenchloride; In dichloromethane; ethyl acetate; at 0 ℃; for 1h;

Reference yield:

(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylic acid hydrochloride salt + methyl [5-chloro-2-(1,2,3,6-tetrahydropyridin-4-yl)phenyl]acetate hydrochloride (455957-78-5) → methyl [2-(1-{[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}-1,2,3,6-tetrahydropyridin-4-yl)-5-chlorophenyl]acetate

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 18h;

upstream raw materials:

tert-butyl 4-[4-chloro-2-(2-methoxy-2-oxoethyl)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate

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