diethyl 5-oxo-1-[(R)-1-phenylethyl]pyrrolidine-3,3-dicarboxylate

Base Information

• Chemical Name: diethyl 5-oxo-1-[(R)-1-phenylethyl]pyrrolidine-3,3-dicarboxylate
• CAS No.: 162685-91-8
• Molecular Formula: C₁₈H₂₃NO₅
• Molecular Weight: 333.384
• Mol file: 162685-91-8.mol

Synonyms:diethyl 5-oxo-1-[(R)-1-phenylethyl]pyrrolidine-3,3-dicarboxylate

Chemical Property of diethyl 5-oxo-1-[(R)-1-phenylethyl]pyrrolidine-3,3-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of diethyl 5-oxo-1-[(R)-1-phenylethyl]pyrrolidine-3,3-dicarboxylate

There total 2 articles about diethyl 5-oxo-1-[(R)-1-phenylethyl]pyrrolidine-3,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triethyl 1,1,2-ethanetricarboxylate (7459-46-3) + 1,3,5-tris<(R)-(+)-phenylethyl>hexahydrotriazine (170716-16-2) → diethyl 5-oxo-1-[(R)-1-phenylethyl]pyrrolidine-3,3-dicarboxylate (162685-91-8)

Guidance literature:

With trifluoroacetic acid; In water; toluene; at 100 ℃; for 24h;

DOI:10.1021/acs.orglett.1c01291

Reference yield:

→ diethyl 5-oxo-1-[(R)-1-phenylethyl]pyrrolidine-3,3-dicarboxylate (162685-91-8)

Guidance literature:

Reference yield: 67.0%

diethyl 5-oxo-1-[(R)-1-phenylethyl]pyrrolidine-3,3-dicarboxylate (162685-91-8) → (R)-3-ethoxycarbonyl-5-oxo-1-[(R)-1-phenylethyl]pyrrolidine-3-carboxylic acid

Guidance literature:

With porcine liver esterase; In aq. phosphate buffer; acetone; at 20 ℃; for 16h; Enzymatic reaction;

DOI:10.1021/acs.orglett.1c01291

upstream raw materials:

triethyl 1,1,2-ethanetricarboxylate

1,3,5-tris<(R)-(+)-phenylethyl>hexahydrotriazine