(S)-methyl 2-(3-(1-(tert-butoxycarbonylamino)-2-phenylethyl)-5-(4-(methoxycarbonylamino)phenyl)-6-oxopyridazin-1(6H)-yl)acetate

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Chemical Name:(S)-methyl 2-(3-(1-(tert-butoxycarbonylamino)-2-phenylethyl)-5-(4-(methoxycarbonylamino)phenyl)-6-oxopyridazin-1(6H)-yl)acetate
CAS No.:1187648-48-1
Molecular Formula:C₂₈H₃₂N₄O₇
Molecular Weight:536.585
Hs Code.:

Synonyms:(S)-methyl 2-(3-(1-(tert-butoxycarbonylamino)-2-phenylethyl)-5-(4-(methoxycarbonylamino)phenyl)-6-oxopyridazin-1(6H)-yl)acetate

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Chemical Property of (S)-methyl 2-(3-(1-(tert-butoxycarbonylamino)-2-phenylethyl)-5-(4-(methoxycarbonylamino)phenyl)-6-oxopyridazin-1(6H)-yl)acetate

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Technology Process of (S)-methyl 2-(3-(1-(tert-butoxycarbonylamino)-2-phenylethyl)-5-(4-(methoxycarbonylamino)phenyl)-6-oxopyridazin-1(6H)-yl)acetate

There total 3 articles about (S)-methyl 2-(3-(1-(tert-butoxycarbonylamino)-2-phenylethyl)-5-(4-(methoxycarbonylamino)phenyl)-6-oxopyridazin-1(6H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.7%

: 1187648-27-6
{4-[6-((S)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-phenyl}-carbamic acid methyl ester

: 96-32-2
bromoacetic acid methyl ester

: 1187648-48-1
(S)-methyl 2-(3-(1-(tert-butoxycarbonylamino)-2-phenylethyl)-5-(4-(methoxycarbonylamino)phenyl)-6-oxopyridazin-1(6H)-yl)acetate

Guidance literature:: {4-[6-((S)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-phenyl}-carbamic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 80 ℃; for 0.5h;

bromoacetic acid methyl ester; In N,N-dimethyl-formamide; at 80 ℃; for 0.583333h;

Reference yield:

: 1187648-25-4
(S)-tert-butyl 1-(5-(4-nitrophenyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-phenylethylcarbamate

: 1187648-48-1
(S)-methyl 2-(3-(1-(tert-butoxycarbonylamino)-2-phenylethyl)-5-(4-(methoxycarbonylamino)phenyl)-6-oxopyridazin-1(6H)-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol

2.1: triethylamine / dichloromethane / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 80 °C

3.2: 0.58 h / 80 °C

With hydrogen; sodium hydride; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1187648-26-5
(S)-tert-butyl 1-(5-(4-aminophenyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-phenylethylcarbamate

: 1187648-48-1
(S)-methyl 2-(3-(1-(tert-butoxycarbonylamino)-2-phenylethyl)-5-(4-(methoxycarbonylamino)phenyl)-6-oxopyridazin-1(6H)-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 80 °C

2.2: 0.58 h / 80 °C

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;