N-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-4-oxo-4H-chromen-6-yl}-methanesulfonamide

Base Information

Chemical Name:N-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-4-oxo-4H-chromen-6-yl}-methanesulfonamide
CAS No.:1256488-32-0
Molecular Formula:C₂₆H₂₆N₂O₆S
Molecular Weight:494.568
Hs Code.:

Synonyms:N-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-4-oxo-4H-chromen-6-yl}-methanesulfonamide

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Chemical Property of N-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-4-oxo-4H-chromen-6-yl}-methanesulfonamide

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Technology Process of N-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-4-oxo-4H-chromen-6-yl}-methanesulfonamide

There total 8 articles about N-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-4-oxo-4H-chromen-6-yl}-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 951655-49-5
(2-oxo-1,2-dihydropyridin-3-yl)boronic acid

: 1256488-72-8
C₂₁H₂₂BrNO₅S

: 1256488-32-0
N-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-4-oxo-4H-chromen-6-yl}-methanesulfonamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; at 115 ℃; for 0.5h; Microwave Irradiation; Sealed tube;

Reference yield:

: 13466-43-8
3-bromopyridin-2(1H)-one

: 1256488-32-0
N-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-4-oxo-4H-chromen-6-yl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 0.5 h / -76 °C

1.2: 15.25 h / 0 - 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; dichloromethane / 0.5 h / 115 °C / Microwave Irradiation; Sealed tube

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; dichloromethane;

Reference yield:

: 24623-65-2
3-tert-butyl-2-hydroxybenzaldehyde

: 1256488-32-0
N-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-4-oxo-4H-chromen-6-yl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: bromine / dichloromethane / 1.5 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C

3: ethanol / 20 °C / Reflux

4: iodine / dimethyl sulfoxide / 1.5 h / Reflux

5: tin(II) chloride dihdyrate / ethyl acetate; N,N-dimethyl-formamide / 0 - 20 °C

6: pyridine / dichloromethane / 0 - 20 °C

7: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; dichloromethane / 0.5 h / 115 °C / Microwave Irradiation; Sealed tube

With pyridine; tin(II) chloride dihdyrate; bromine; iodine; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;