(2S,4Z)-2-tert-butoxycarbonylamino-5-cyano-5-(2,3-difluorophenyl)pent-4-enoic acid ethyl ester

Base Information

Chemical Name:(2S,4Z)-2-tert-butoxycarbonylamino-5-cyano-5-(2,3-difluorophenyl)pent-4-enoic acid ethyl ester
CAS No.:1019107-61-9
Molecular Formula:C₁₉H₂₂F₂N₂O₄
Molecular Weight:380.391
Hs Code.:

Synonyms:(2S,4Z)-2-tert-butoxycarbonylamino-5-cyano-5-(2,3-difluorophenyl)pent-4-enoic acid ethyl ester

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Chemical Property of (2S,4Z)-2-tert-butoxycarbonylamino-5-cyano-5-(2,3-difluorophenyl)pent-4-enoic acid ethyl ester

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Technology Process of (2S,4Z)-2-tert-butoxycarbonylamino-5-cyano-5-(2,3-difluorophenyl)pent-4-enoic acid ethyl ester

There total 1 articles about (2S,4Z)-2-tert-butoxycarbonylamino-5-cyano-5-(2,3-difluorophenyl)pent-4-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145689-34-5
2-(2,3-difluorophenyl)acetonitrile

: 1019107-54-0
(S)-2-tert-butoxycarbonylamino-4-oxo-butyric acid ethyl ester

: (2S,4E)-2-tert-butoxycarbonylamino-5-cyano-5-(2,3-difluorophenyl)pent-4-enoic acid ethyl ester

: 1019107-61-9
(2S,4Z)-2-tert-butoxycarbonylamino-5-cyano-5-(2,3-difluorophenyl)pent-4-enoic acid ethyl ester

Guidance literature:: 2-(2,3-difluorophenyl)acetonitrile; With lithium hexamethyldisilazane; In tetrahydrofuran; at -35 ℃; for 0.25h;

(S)-2-tert-butoxycarbonylamino-4-oxo-butyric acid ethyl ester; In tetrahydrofuran; at -30 ℃;

With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at -30 - 20 ℃; Further stages.;
DOI:10.1021/jo8000996

Reference yield:

: 1019107-61-9
(2S,4Z)-2-tert-butoxycarbonylamino-5-cyano-5-(2,3-difluorophenyl)pent-4-enoic acid ethyl ester

: 1019107-53-9
[(3S)-6-(2,3-difluorophenyl)-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl]carbamic acid tert-butyl ester

: [(3R)-6-(2,3-difluorophenyl)-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl]carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; triethylamine; In methanol; at 40 ℃; for 8h; under 23272.3 Torr; Title compound not separated from byproducts.;
DOI:10.1021/jo8000996