N₃-cyclopropyl-N₄'-(2,2-dimethylpropyl)-5-fluoro-6-methyl-2'-({[(phenylmethyl)amino]carbonyl}amino)-3,4'-biphenyldicarboxamide

Base Information

• Chemical Name: N₃-cyclopropyl-N₄'-(2,2-dimethylpropyl)-5-fluoro-6-methyl-2'-({[(phenylmethyl)amino]carbonyl}amino)-3,4'-biphenyldicarboxamide
• CAS No.: 913002-54-7
• Molecular Formula: C₃₁H₃₅FN₄O₃
• Molecular Weight: 530.642

Synonyms:N₃-cyclopropyl-N₄'-(2,2-dimethylpropyl)-5-fluoro-6-methyl-2'-({[(phenylmethyl)amino]carbonyl}amino)-3,4'-biphenyldicarboxamide

Chemical Property of N₃-cyclopropyl-N₄'-(2,2-dimethylpropyl)-5-fluoro-6-methyl-2'-({[(phenylmethyl)amino]carbonyl}amino)-3,4'-biphenyldicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N₃-cyclopropyl-N₄'-(2,2-dimethylpropyl)-5-fluoro-6-methyl-2'-({[(phenylmethyl)amino]carbonyl}amino)-3,4'-biphenyldicarboxamide

There total 8 articles about N₃-cyclopropyl-N₄'-(2,2-dimethylpropyl)-5-fluoro-6-methyl-2'-({[(phenylmethyl)amino]carbonyl}amino)-3,4'-biphenyldicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

2'-amino-N3-cyclopropyl-N4'-(2,2-dimethylpropyl)-5-fluoro-6-methyl-3,4'-biphenyldicarboxamide + benzyl isothiocyanate (3173-56-6) → N3-cyclopropyl-N4'-(2,2-dimethylpropyl)-5-fluoro-6-methyl-2'-({[(phenylmethyl)amino]carbonyl}amino)-3,4'-biphenyldicarboxamide (913002-54-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

2-bromo-5-{[(2,2-dimethylpropyl)amino]carbonyl}benzoic acid → N3-cyclopropyl-N4'-(2,2-dimethylpropyl)-5-fluoro-6-methyl-2'-({[(phenylmethyl)amino]carbonyl}amino)-3,4'-biphenyldicarboxamide (913002-54-7)

Guidance literature:

Multi-step reaction with 3 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 0.5 h / 100 °C / Irradiation

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 150 °C / Irradiation

3: triethylamine / N,N-dimethyl-formamide / 20 °C

With diphenyl phosphoryl azide; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

3-fluoro-5-iodo-4-methylbenzoic acid (861905-94-4) → N3-cyclopropyl-N4'-(2,2-dimethylpropyl)-5-fluoro-6-methyl-2'-({[(phenylmethyl)amino]carbonyl}amino)-3,4'-biphenyldicarboxamide (913002-54-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: oxalyl dichloride / dichloromethane / 2 h / 0 - 20 °C

1.2: 3 h / 0 - 20 °C

2.1: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; palladium dichloride / N,N-dimethyl-formamide / 4 h / 90 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 150 °C / Irradiation

4.1: triethylamine / N,N-dimethyl-formamide / 20 °C

With oxalyl dichloride; potassium acetate; potassium carbonate; triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium dichloride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

benzyl isothiocyanate

N-cyclopropyl-5-fluoro-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzamide

phenylmethyl (2-bromo-5-{[(2,2-dimethylpropyl)amino]carbonyl}phenyl)carbamate

3-fluoro-5-iodo-4-methylbenzoic acid

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