(3R)-3-(2-(2-(methoxycarbonyl)thiophen-3-ylamino)-2-phenylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide

Base Information

Chemical Name:(3R)-3-(2-(2-(methoxycarbonyl)thiophen-3-ylamino)-2-phenylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide
CAS No.:1352450-12-4
Molecular Formula:Br*C₃₀H₃₅N₂O₅S
Molecular Weight:615.588
Hs Code.:

Synonyms:(3R)-3-(2-(2-(methoxycarbonyl)thiophen-3-ylamino)-2-phenylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide

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Chemical Property of (3R)-3-(2-(2-(methoxycarbonyl)thiophen-3-ylamino)-2-phenylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide

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Technology Process of (3R)-3-(2-(2-(methoxycarbonyl)thiophen-3-ylamino)-2-phenylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide

There total 5 articles about (3R)-3-(2-(2-(methoxycarbonyl)thiophen-3-ylamino)-2-phenylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.9%

: 1233326-89-0
methyl 3-(2-oxo-1-phenyl-2-((R)-quinuclidin-3-yloxy)ethylamino)thiophene-2-carboxylate

: 588-63-6
3-phenoxypropyl bromide

: 1352450-12-4
(3R)-3-(2-(2-(methoxycarbonyl)thiophen-3-ylamino)-2-phenylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide

Guidance literature:: In ethyl acetate; at 20 ℃;

Reference yield: 32.9%

: methyl 3-(2-oxo-1-phenyl-2-((R)-quinuclidin-3-yloxy)ethylamino)thiophene-2-carboxylate (C₁₁)

: 588-63-6
3-phenoxypropyl bromide

: 1352450-12-4
(3R)-3-(2-(2-(methoxycarbonyl)thiophen-3-ylamino)-2-phenylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide

Guidance literature:: In ethyl acetate;

Reference yield:

: 98-80-6
phenylboronic acid

: 1352450-12-4
(3R)-3-(2-(2-(methoxycarbonyl)thiophen-3-ylamino)-2-phenylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 2 h / 20 °C

2: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 20 °C

3: ethyl acetate / 20 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethyl acetate; acetonitrile;