(rac)-tert-butyl (1-(4-(4-(3-(tert-butyl)-4-isopropoxyphenyl)pyrimidin-2-yl)phenyl)-2-hydroxyethyl)carbamate

Base Information

Chemical Name:(rac)-tert-butyl (1-(4-(4-(3-(tert-butyl)-4-isopropoxyphenyl)pyrimidin-2-yl)phenyl)-2-hydroxyethyl)carbamate
CAS No.:1378368-30-9
Molecular Formula:C₃₀H₃₉N₃O₄
Molecular Weight:505.657
Hs Code.:

Synonyms:(rac)-tert-butyl (1-(4-(4-(3-(tert-butyl)-4-isopropoxyphenyl)pyrimidin-2-yl)phenyl)-2-hydroxyethyl)carbamate

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Chemical Property of (rac)-tert-butyl (1-(4-(4-(3-(tert-butyl)-4-isopropoxyphenyl)pyrimidin-2-yl)phenyl)-2-hydroxyethyl)carbamate

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Technology Process of (rac)-tert-butyl (1-(4-(4-(3-(tert-butyl)-4-isopropoxyphenyl)pyrimidin-2-yl)phenyl)-2-hydroxyethyl)carbamate

There total 8 articles about (rac)-tert-butyl (1-(4-(4-(3-(tert-butyl)-4-isopropoxyphenyl)pyrimidin-2-yl)phenyl)-2-hydroxyethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1378367-44-2
4-(3-(tert-butyl)-4-isopropoxyphenyl)-2-chloropyrimidine

: 1378368-27-4
(rac)-tert-butyl (2-hydroxy-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)carbamate

: 1378368-30-9
(rac)-tert-butyl (1-(4-(4-(3-(tert-butyl)-4-isopropoxyphenyl)pyrimidin-2-yl)phenyl)-2-hydroxyethyl)carbamate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 120 ℃; for 0.666667h; Inert atmosphere; Sealed; microwave irradiation;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1378368-30-9
(rac)-tert-butyl (1-(4-(4-(3-(tert-butyl)-4-isopropoxyphenyl)pyrimidin-2-yl)phenyl)-2-hydroxyethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 20 °C

2: potassium acetate; 1,3-diisopropyl-1H-imidazol-3-ium chloride / palladium diacetate / tetrahydrofuran / 2 h / 80 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.67 h / 120 °C / Inert atmosphere; Sealed; microwave irradiation

With potassium acetate; sodium carbonate; triethylamine; 1,3-diisopropyl-1H-imidazol-3-ium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 10323-39-4
4-bromo-2-tert-butylphenol

: 1378368-30-9
(rac)-tert-butyl (1-(4-(4-(3-(tert-butyl)-4-isopropoxyphenyl)pyrimidin-2-yl)phenyl)-2-hydroxyethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 18 h / 20 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.67 h / 120 °C / Inert atmosphere; Sealed; microwave irradiation

With potassium acetate; sodium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;