(3-{[5-(4-Ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid

Base Information

Chemical Name:(3-{[5-(4-Ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid
CAS No.:1092938-69-6
Molecular Formula:C₂₈H₂₇N₃O₄
Molecular Weight:469.54
Hs Code.:

Synonyms:(3-{[5-(4-Ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid

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Chemical Property of (3-{[5-(4-Ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid

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Technology Process of (3-{[5-(4-Ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid

There total 5 articles about (3-{[5-(4-Ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.3%

: 1092938-90-3
2-(4-ethylcyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1092938-95-8
methyl {3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]phenoxy}acetate

: 1092938-69-6
(3-{[5-(4-Ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid

Guidance literature:: With water; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In dimethyl sulfoxide; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 554-84-7
meta-nitrophenol

: 1092938-69-6
(3-{[5-(4-Ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / acetone / 1 h / 50 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / 0.5 h / 180 °C / microwave irradiation

4: water; sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere

With water; hydrogen; sodium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In methanol; dimethyl sulfoxide; acetone;

Reference yield:

: 81720-19-6
1-methoxycarbonylmethyloxy-3-nitrobenzene

: 1092938-69-6
(3-{[5-(4-Ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / 0.5 h / 180 °C / microwave irradiation

3: water; sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere

With water; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In methanol; dimethyl sulfoxide;