4-amino-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazine-5-thiocarboxamide

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Chemical Name:4-amino-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazine-5-thiocarboxamide
CAS No.:855869-55-5
Molecular Formula:C₃₂H₂₆N₆O₇S
Molecular Weight:638.66
Hs Code.:

Synonyms:4-amino-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazine-5-thiocarboxamide

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Chemical Property of 4-amino-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazine-5-thiocarboxamide

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Technology Process of 4-amino-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazine-5-thiocarboxamide

There total 7 articles about 4-amino-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazine-5-thiocarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 855869-41-9
4-amino-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazine-5-carbonitrile

: 855869-55-5
4-amino-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazine-5-thiocarboxamide

Guidance literature:: With sodium hydrogensulfide; In methanol; at 90 ℃; for 1h;
DOI:10.1021/jm0402014

Reference yield:

: 855869-34-0
2-nitro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrole-3,4-dicarboxamide

: 855869-55-5
4-amino-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazine-5-thiocarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 263 mg / H₂ / Pd/C / ethanol; tetrahydrofuran / 18 h / 2068.59 Torr

2.1: 71 percent / aq. NaNO₂; HCl / acetonitrile / -40 - 0 °C

3.1: POCl₃; Et₃N / acetonitrile / 1 h / 0 °C

3.2: 58 percent / acetonitrile / 1.5 h / 20 °C

4.1: 49 percent / NH₃ / dioxane; acetonitrile / 168 h / 45 °C

5.1: NaSH / methanol / 1 h / 90 °C

With hydrogenchloride; sodium hydrogensulfide; ammonia; hydrogen; triethylamine; sodium nitrite; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; acetonitrile;
DOI:10.1021/jm0402014

Reference yield:

: 5991-01-5
2,3,5-(tri-O-benzoyl)-D-ribofuranosyl chloride

: 855869-55-5
4-amino-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazine-5-thiocarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 263 mg / H₂ / Pd/C / ethanol; tetrahydrofuran / 18 h / 2068.59 Torr

2.1: 71 percent / aq. NaNO₂; HCl / acetonitrile / -40 - 0 °C

3.1: POCl₃; Et₃N / acetonitrile / 1 h / 0 °C

3.2: 58 percent / acetonitrile / 1.5 h / 20 °C

4.1: 49 percent / NH₃ / dioxane; acetonitrile / 168 h / 45 °C

5.1: NaSH / methanol / 1 h / 90 °C

With hydrogenchloride; sodium hydrogensulfide; ammonia; hydrogen; triethylamine; sodium nitrite; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; acetonitrile;
DOI:10.1021/jm0402014