(1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-ol

Base Information

Chemical Name:(1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-ol
CAS No.:1256257-76-7
Molecular Formula:C₃₁H₄₅NO₂SSi
Molecular Weight:523.855
Hs Code.:

Synonyms:(1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-ol

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Chemical Property of (1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-ol

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Technology Process of (1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-ol

There total 5 articles about (1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₅₃NO₄SSi

: 1256257-76-7
(1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-ol

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1002/ejoc.200901151

Reference yield:

: 1215035-73-6
C₃₃H₄₃NO₆SSi

: 1256257-76-7
(1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate; methanol / 1,2-dichloro-ethane / 3 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.2: pH 9

With methanol; sodium tetrahydroborate; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 194089-91-3
tert-butyl (2S,4R)-4-hydroxy-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)-pyrrolidine-1-carboxylate

: 1256257-76-7
(1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / 48 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate; methanol / 1,2-dichloro-ethane / 3 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.2: pH 9

With methanol; dmap; sodium tetrahydroborate; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;