1-acetyl-5-broMo-2,3-dihydro-1H-indole-6-sulfonyl chloride

Base Information

• Chemical Name: 1-acetyl-5-broMo-2,3-dihydro-1H-indole-6-sulfonyl chloride
• CAS No.: 107144-42-3
• Molecular Formula: C₁₀H₉BrClNO₃S
• Molecular Weight: 338.609
• Mol file: 107144-42-3.mol

Synonyms:1‐acetyl 5‐bromoindoline‐6‐sulfonyl chloride

Chemical Property of 1-acetyl-5-broMo-2,3-dihydro-1H-indole-6-sulfonyl chloride

Chemical Property:

Purity/Quality:

1-Acetyl-5-bromo-2,3-dihydro-1H-indole-6-sulfonylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-acetyl-5-broMo-2,3-dihydro-1H-indole-6-sulfonyl chloride

There total 3 articles about 1-acetyl-5-broMo-2,3-dihydro-1H-indole-6-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-bromo-N-acetylindoline (22190-38-1) → 1‐acetyl 5‐bromoindoline‐6‐sulfonyl chloride (107144-42-3)

Guidance literature:

With chlorosulfonic acid; at 70 ℃; Inert atmosphere; Cooling with ice;

Reference yield:

1-Acetyl-2,3-dihydro-1H-indole (16078-30-1) → 1‐acetyl 5‐bromoindoline‐6‐sulfonyl chloride (107144-42-3)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / acetic acid / 0.17 h / 20 °C / Inert atmosphere

2: chlorosulfonic acid / 12 h / 80 °C / Inert atmosphere; Neat (no solvent)

With chlorosulfonic acid; bromine; In acetic acid;

DOI:10.1002/adsc.201000465

Reference yield:

1-indoline (496-15-1) → 1‐acetyl 5‐bromoindoline‐6‐sulfonyl chloride (107144-42-3)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2: bromine / acetic acid / 0.17 h / 20 °C / Inert atmosphere

3: chlorosulfonic acid / 12 h / 80 °C / Inert atmosphere; Neat (no solvent)

With chlorosulfonic acid; bromine; In dichloromethane; acetic acid;

DOI:10.1002/adsc.201000465

upstream raw materials:

5-bromo-N-acetylindoline

1-indoline

1-Acetyl-2,3-dihydro-1H-indole

Refernces

• 1、 -. "INDOLINE SULFONAMIDE INHIBITORS OF DAPE AND NDM-1 AND USE OF THE SAME". Paragraph 00116. . Retrieved 2016/02/29.
• 2、 -. "BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY". Page/Page column 132. . Retrieved 2012/11/07.