N--3-<(triphenylmethyl)thio>-D-valyl>glycyl>-L-phenylalanyl>-3-mercapto-D-valine

Base Information

Chemical Name:N--3-<(triphenylmethyl)thio>-D-valyl>glycyl>-L-phenylalanyl>-3-mercapto-D-valine
CAS No.:142929-45-1
Molecular Formula:C₄₆H₅₆N₄O₇S₂
Molecular Weight:841.105
Hs Code.:

N-<N-<N-<N-<(1,1-dimethylethoxy)carbonyl>-3-<(triphenylmethyl)thio>-D-valyl>glycyl>-L-phenylalanyl>-3-mercapto-D-valine

Synonyms:N--3-<(triphenylmethyl)thio>-D-valyl>glycyl>-L-phenylalanyl>-3-mercapto-D-valine

Suppliers and Price of N--3-<(triphenylmethyl)thio>-D-valyl>glycyl>-L-phenylalanyl>-3-mercapto-D-valine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N--3-<(triphenylmethyl)thio>-D-valyl>glycyl>-L-phenylalanyl>-3-mercapto-D-valine

Chemical Property:

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Technology Process of N--3-<(triphenylmethyl)thio>-D-valyl>glycyl>-L-phenylalanyl>-3-mercapto-D-valine

There total 7 articles about N--3-<(triphenylmethyl)thio>-D-valyl>glycyl>-L-phenylalanyl>-3-mercapto-D-valine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29913-83-5
D-penicillamine methyl ester

: C₄₅H₅₃N₃O₈S

: 142929-45-1
N--3-<(triphenylmethyl)thio>-D-valyl>glycyl>-L-phenylalanyl>-3-mercapto-D-valine

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; at -23 - 20 ℃; for 16h; Yield given;
DOI:10.1021/jm00094a002

Reference yield:

: 106624-70-8,41889-06-9
methyl (2S)-2-[[2-(t-butoxycarbonylamino)acetyl]amino]-3-phenylpropanoate

: 142929-45-1
N--3-<(triphenylmethyl)thio>-D-valyl>glycyl>-L-phenylalanyl>-3-mercapto-D-valine

Guidance literature:: Multi-step reaction with 5 steps

1: HCl(gas.) / CH₂Cl₂; dioxane / 0.25 h / Ambient temperature

2: 1-methylmorpholine (NMM) / tetrahydrofuran; dimethylformamide / 16 h / -23 - 20 °C

3: 90 percent / aq. LiOH / tetrahydrofuran / 0.5 h / 0 °C

4: 1-methylmorpholine (NMM) / tetrahydrofuran / 0.75 h / -23 °C

5: 1-methylmorpholine (NMM) / tetrahydrofuran; dimethylformamide / 16 h / -23 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00094a002

Reference yield:

: 16227-22-8,16227-24-0,97372-81-1
glycyl-L-phenylalanine methyl ester

: 142929-45-1
N--3-<(triphenylmethyl)thio>-D-valyl>glycyl>-L-phenylalanyl>-3-mercapto-D-valine

Guidance literature:: Multi-step reaction with 4 steps

1: 1-methylmorpholine (NMM) / tetrahydrofuran; dimethylformamide / 16 h / -23 - 20 °C

2: 90 percent / aq. LiOH / tetrahydrofuran / 0.5 h / 0 °C

3: 1-methylmorpholine (NMM) / tetrahydrofuran / 0.75 h / -23 °C

4: 1-methylmorpholine (NMM) / tetrahydrofuran; dimethylformamide / 16 h / -23 - 20 °C

With 4-methyl-morpholine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00094a002