(+/-)-N-(3,4-dimethoxybenzyl)-N-[2-hydroxy-2-(1H-tetrazol-5-yl)propyl]benzenesulfonamide

Base Information

Chemical Name:(+/-)-N-(3,4-dimethoxybenzyl)-N-[2-hydroxy-2-(1H-tetrazol-5-yl)propyl]benzenesulfonamide
CAS No.:1362100-87-5
Molecular Formula:C₁₉H₂₃N₅O₅S
Molecular Weight:433.488
Hs Code.:

Synonyms:(+/-)-N-(3,4-dimethoxybenzyl)-N-[2-hydroxy-2-(1H-tetrazol-5-yl)propyl]benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-N-(3,4-dimethoxybenzyl)-N-[2-hydroxy-2-(1H-tetrazol-5-yl)propyl]benzenesulfonamide

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Technology Process of (+/-)-N-(3,4-dimethoxybenzyl)-N-[2-hydroxy-2-(1H-tetrazol-5-yl)propyl]benzenesulfonamide

There total 3 articles about (+/-)-N-(3,4-dimethoxybenzyl)-N-[2-hydroxy-2-(1H-tetrazol-5-yl)propyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1362100-75-1
(+/-)-N-[2-(1-allyl-1H-tetrazol-5-yl)-2-hydroxypropyl]-N-(3,4-dimethoxybenzyl)benzenesulfonamide

: 1362100-87-5
(+/-)-N-(3,4-dimethoxybenzyl)-N-[2-hydroxy-2-(1H-tetrazol-5-yl)propyl]benzenesulfonamide

Guidance literature:: (+/-)-N-[2-(1-allyl-1H-tetrazol-5-yl)-2-hydroxypropyl]-N-(3,4-dimethoxybenzyl)benzenesulfonamide; With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; tert-butylmagnesium chloride; In tetrahydrofuran; dichloromethane; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; dichloromethane; water; at 20 ℃; Inert atmosphere;
DOI:10.1021/ol300276p

Reference yield:

: 1362099-95-3
N-(3,4-dimethoxybenzyl)-N-prop-2-ynylbenzenesulfonamide

: 1362100-87-5
(+/-)-N-(3,4-dimethoxybenzyl)-N-[2-hydroxy-2-(1H-tetrazol-5-yl)propyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; water; mercury(II) sulfate / methanol / 20 °C

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 0.05 h / -98 °C / Inert atmosphere

2.2: 2 h / -98 - -60 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; tert-butylmagnesium chloride / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With n-butyllithium; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; tert-butylmagnesium chloride; water; mercury(II) sulfate; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ol300276p

Reference yield:

: 1362099-97-5
N-(3,4-dimethoxybenzyl)-N-(2-oxopropyl)benzenesulfonamide

: 1362100-87-5
(+/-)-N-(3,4-dimethoxybenzyl)-N-[2-hydroxy-2-(1H-tetrazol-5-yl)propyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 0.05 h / -98 °C / Inert atmosphere

1.2: 2 h / -98 - -60 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; tert-butylmagnesium chloride / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With n-butyllithium; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; N,N,N,N,-tetramethylethylenediamine; tert-butylmagnesium chloride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol300276p