(2R,3S)-2,3-bis(methoxymethoxy)-3-[3',4'-bis(methoxymethoxy)phenyl]propionaldehyde

Base Information

Chemical Name:(2R,3S)-2,3-bis(methoxymethoxy)-3-[3',4'-bis(methoxymethoxy)phenyl]propionaldehyde
CAS No.:1026679-32-2
Molecular Formula:C₁₇H₂₆O₉
Molecular Weight:374.388
Hs Code.:

Synonyms:(2R,3S)-2,3-bis(methoxymethoxy)-3-[3',4'-bis(methoxymethoxy)phenyl]propionaldehyde

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Chemical Property of (2R,3S)-2,3-bis(methoxymethoxy)-3-[3',4'-bis(methoxymethoxy)phenyl]propionaldehyde

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Technology Process of (2R,3S)-2,3-bis(methoxymethoxy)-3-[3',4'-bis(methoxymethoxy)phenyl]propionaldehyde

There total 4 articles about (2R,3S)-2,3-bis(methoxymethoxy)-3-[3',4'-bis(methoxymethoxy)phenyl]propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 455952-02-0
methyl (2R,3S)-2,3-bis(methoxymethoxy)-3-[3',4'-bis(methoxymethoxy)phenyl]propionate

: 1026679-32-2
(2R,3S)-2,3-bis(methoxymethoxy)-3-[3',4'-bis(methoxymethoxy)phenyl]propionaldehyde

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 1h;
DOI:10.1016/S0957-4166(02)00182-9

Reference yield:

: 3843-74-1,67667-67-8
Methyl caffeate

: 1026679-32-2
(2R,3S)-2,3-bis(methoxymethoxy)-3-[3',4'-bis(methoxymethoxy)phenyl]propionaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / NaH / dimethylformamide / 1 h / 20 °C

2: 100 percent / AD-mix-α; methanesulfonamide / 2-methyl-propan-2-ol; H2O / 5 h / 20 °C

3: 89 percent / i-Pr₂NEt / CH₂Cl₂ / 0 - 20 °C

4: 87 percent / DIBAL-H / toluene / 1 h / -78 °C

With AD-mix-α; methanesulfonamide; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 2: Sharpless asymmetric dihydroxylation;
DOI:10.1016/S0957-4166(02)00182-9

Reference yield:

: 114590-76-0
(E)-methyl 3-(3,4-bis(methoxymethoxy)phenyl)acrylate

: 1026679-32-2
(2R,3S)-2,3-bis(methoxymethoxy)-3-[3',4'-bis(methoxymethoxy)phenyl]propionaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / AD-mix-α; methanesulfonamide / 2-methyl-propan-2-ol; H2O / 5 h / 20 °C

2: 89 percent / i-Pr₂NEt / CH₂Cl₂ / 0 - 20 °C

3: 87 percent / DIBAL-H / toluene / 1 h / -78 °C

With AD-mix-α; methanesulfonamide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; toluene; tert-butyl alcohol; 1: Sharpless asymmetric dihydroxylation;
DOI:10.1016/S0957-4166(02)00182-9