methyl (S)-2-((S)-2-((S)-2-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyl)-2'-oxo-2,4-dihydro-1H-spiro[isoquinoline-3,3'-pyrrolidin]-1'-yl)propanamido)-5-((E)-2-nitroguanidino)pentanoate

Base Information

• Chemical Name: methyl (S)-2-((S)-2-((S)-2-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyl)-2'-oxo-2,4-dihydro-1H-spiro[isoquinoline-3,3'-pyrrolidin]-1'-yl)propanamido)-5-((E)-2-nitroguanidino)pentanoate
• CAS No.: 1191929-84-6
• Molecular Formula: C₃₇H₅₀N₈O₁₀
• Molecular Weight: 766.852
• Mol file: 1191929-84-6.mol

Synonyms:methyl (S)-2-((S)-2-((S)-2-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyl)-2'-oxo-2,4-dihydro-1H-spiro[isoquinoline-3,3'-pyrrolidin]-1'-yl)propanamido)-5-((E)-2-nitroguanidino)pentanoate

Chemical Property of methyl (S)-2-((S)-2-((S)-2-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyl)-2'-oxo-2,4-dihydro-1H-spiro[isoquinoline-3,3'-pyrrolidin]-1'-yl)propanamido)-5-((E)-2-nitroguanidino)pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl (S)-2-((S)-2-((S)-2-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyl)-2'-oxo-2,4-dihydro-1H-spiro[isoquinoline-3,3'-pyrrolidin]-1'-yl)propanamido)-5-((E)-2-nitroguanidino)pentanoate

There total 1 articles about methyl (S)-2-((S)-2-((S)-2-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyl)-2'-oxo-2,4-dihydro-1H-spiro[isoquinoline-3,3'-pyrrolidin]-1'-yl)propanamido)-5-((E)-2-nitroguanidino)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(S)-2-((S)-2-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)-propanoyl)-2'-oxo-2,4-dihydro-1H-spiro[isoquinoline-3,3'-pyrrolidin]-1'-yl)propanoic acid (1191929-82-4) + Nη-nitro-L-arginine methyl ester hydrochloride → methyl (S)-2-((S)-2-((S)-2-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propanoyl)-2'-oxo-2,4-dihydro-1H-spiro[isoquinoline-3,3'-pyrrolidin]-1'-yl)propanamido)-5-((E)-2-nitroguanidino)pentanoate (1191929-84-6)

Guidance literature:

(S)-2-((S)-2-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)-propanoyl)-2'-oxo-2,4-dihydro-1H-spiro[isoquinoline-3,3'-pyrrolidin]-1'-yl)propanoic acid; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 0 ℃; for 0.666667h; Inert atmosphere;

N^η-nitro-L-arginine methyl ester hydrochloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo901480d

upstream raw materials:

(S)-2-((S)-2-((S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)-propanoyl)-2'-oxo-2,4-dihydro-1H-spiro[isoquinoline-3,3'-pyrrolidin]-1'-yl)propanoic acid