tert-butyl 3-amino-4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)benzoate

Base Information

• Chemical Name: tert-butyl 3-amino-4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)benzoate
• CAS No.: 1012060-15-9
• Molecular Formula: C₂₈H₃₂ClN₃O₂
• Molecular Weight: 478.034

Synonyms:tert-butyl 3-amino-4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)benzoate

Chemical Property of tert-butyl 3-amino-4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)benzoate

Chemical Property:

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Technology Process of tert-butyl 3-amino-4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)benzoate

There total 1 articles about tert-butyl 3-amino-4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.3%

tert-butyl 4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-3-nitrobenzoate (1012060-14-8) → tert-butyl 3-amino-4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)benzoate (1012060-15-9)

Guidance literature:

With hydrogenchloride; iron; In methanol; for 4h;

Reference yield: 92.7%

methyl 8-chloro-8-oxooctanoate (41624-92-4) + tert-butyl 3-amino-4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)benzoate (1012060-15-9) → tert-butyl 4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-3-(8-methoxy-8-oxooctanamido)benzoate (1012060-22-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield: 81.1%

methyl 4-(chlorocarbonyl)butyrate (1501-26-4) + tert-butyl 3-amino-4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)benzoate (1012060-15-9) → tert-butyl 4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-3-(5-methoxy-5-oxopentanamido)benzoate (1012060-16-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

tert-butyl 4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-3-nitrobenzoate

Downstream raw materials:

tert-butyl 4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-3-(5-methoxy-5-oxopentanamido)benzoate

tert-butyl 4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-3-(8-methoxy-8-oxooctanamido)benzoate

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