N-(2-iodophenyl)-4-methoxy-N-(methoxymethyl)-9H-carbazole-3-carboxamide

Base Information

Chemical Name:N-(2-iodophenyl)-4-methoxy-N-(methoxymethyl)-9H-carbazole-3-carboxamide
CAS No.:1425235-49-9
Molecular Formula:C₂₂H₁₉IN₂O₃
Molecular Weight:486.309
Hs Code.:

Synonyms:N-(2-iodophenyl)-4-methoxy-N-(methoxymethyl)-9H-carbazole-3-carboxamide

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Chemical Property of N-(2-iodophenyl)-4-methoxy-N-(methoxymethyl)-9H-carbazole-3-carboxamide

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Technology Process of N-(2-iodophenyl)-4-methoxy-N-(methoxymethyl)-9H-carbazole-3-carboxamide

There total 5 articles about N-(2-iodophenyl)-4-methoxy-N-(methoxymethyl)-9H-carbazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1425235-47-7
N-(2-iodophenyl)-4-methoxy-9H-carbazole-3-carboxamide

: 1425235-49-9
N-(2-iodophenyl)-4-methoxy-N-(methoxymethyl)-9H-carbazole-3-carboxamide

Guidance literature:: With Dimethoxymethane; phosphorus pentoxide; In chloroform; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.1021/jo302821v

Reference yield:

: 1425235-45-5
4-methoxy-9H-carbazole-3-carbaldehyde

: 1425235-49-9
N-(2-iodophenyl)-4-methoxy-N-(methoxymethyl)-9H-carbazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: dihydrogen peroxide; potassium dihydrogenphosphate; sodium chlorite / tetrahydrofuran; water / 8 h / 20 °C

2: thionyl chloride / chloroform / 6 h / Reflux

3: potassium carbonate / tetrahydrofuran / 12 h / 20 °C

4: phosphorus pentoxide; Dimethoxymethane / chloroform / 8 h / 20 °C / Inert atmosphere

With sodium chlorite; potassium dihydrogenphosphate; thionyl chloride; Dimethoxymethane; phosphorus pentoxide; dihydrogen peroxide; potassium carbonate; In tetrahydrofuran; chloroform; water;
DOI:10.1021/jo302821v

Reference yield:

: 6933-50-2
4-methoxy-9H-carbazole

: 1425235-49-9
N-(2-iodophenyl)-4-methoxy-N-(methoxymethyl)-9H-carbazole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 1,2-dichloro-benzene / 3 h / 70 °C / Cooling with ice

2: dihydrogen peroxide; potassium dihydrogenphosphate; sodium chlorite / tetrahydrofuran; water / 8 h / 20 °C

3: thionyl chloride / chloroform / 6 h / Reflux

4: potassium carbonate / tetrahydrofuran / 12 h / 20 °C

5: phosphorus pentoxide; Dimethoxymethane / chloroform / 8 h / 20 °C / Inert atmosphere

With sodium chlorite; potassium dihydrogenphosphate; thionyl chloride; Dimethoxymethane; phosphorus pentoxide; dihydrogen peroxide; potassium carbonate; trichlorophosphate; In tetrahydrofuran; chloroform; water; 1,2-dichloro-benzene; 1: |Vilsmeier-Haack Formylation;
DOI:10.1021/jo302821v