methyl (2S)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-4-difluoromethylidenepyrrolidine-2-carboxylate

Base Information

Chemical Name:methyl (2S)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-4-difluoromethylidenepyrrolidine-2-carboxylate
CAS No.:808154-68-9
Molecular Formula:C₂₂H₂₀F₂N₂O₇
Molecular Weight:462.407
Hs Code.:

Synonyms:methyl (2S)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-4-difluoromethylidenepyrrolidine-2-carboxylate

Suppliers and Price of methyl (2S)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-4-difluoromethylidenepyrrolidine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (2S)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-4-difluoromethylidenepyrrolidine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (2S)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-4-difluoromethylidenepyrrolidine-2-carboxylate

There total 7 articles about methyl (2S)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-4-difluoromethylidenepyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 808154-68-9
methyl (2S)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-4-difluoromethylidenepyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / aq. NaOH / tetrahydrofuran / 20 °C

2: trichloroisocyanuric acid; TEMPO / CH₂Cl₂

3: HMPT; Zn / tetrahydrofuran

4: TFA / CH₂Cl₂

5: Et₃N / dimethylformamide; tetrahydrofuran

With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydroxide; trichloroisocyanuric acid; triethylamine; trifluoroacetic acid; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.08.050

Reference yield:

: 60547-92-4
4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid

: 808154-68-9
methyl (2S)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-4-difluoromethylidenepyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: (COCl)2; DMF / tetrahydrofuran

2: Et₃N / dimethylformamide; tetrahydrofuran

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.08.050

Reference yield:

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 808154-68-9
methyl (2S)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-4-difluoromethylidenepyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: trichloroisocyanuric acid; TEMPO / CH₂Cl₂

2: HMPT; Zn / tetrahydrofuran

3: TFA / CH₂Cl₂

4: Et₃N / dimethylformamide; tetrahydrofuran

With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; trichloroisocyanuric acid; triethylamine; trifluoroacetic acid; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.08.050