2-[3-(2-Imidazol-1-yl-ethyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-benzoic acid ethyl ester

Base Information

Chemical Name:2-[3-(2-Imidazol-1-yl-ethyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-benzoic acid ethyl ester
CAS No.:152567-69-6
Molecular Formula:C₂₂H₂₀N₄O₃
Molecular Weight:388.426
Hs Code.:

Synonyms:2-[3-(2-Imidazol-1-yl-ethyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-benzoic acid ethyl ester

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Chemical Property of 2-[3-(2-Imidazol-1-yl-ethyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-benzoic acid ethyl ester

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Technology Process of 2-[3-(2-Imidazol-1-yl-ethyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-benzoic acid ethyl ester

There total 7 articles about 2-[3-(2-Imidazol-1-yl-ethyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 152567-93-6
2-(4-Oxo-3,4-dihydro-phthalazin-1-yl)-benzoic acid ethyl ester

: 94614-84-3
1-(2-bromoethyl)imidazole hydrogen bromide

: 152567-69-6
2-[3-(2-Imidazol-1-yl-ethyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-benzoic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 5h;
DOI:10.1021/jm00077a008

Reference yield:

: 1615-14-1
1-(2-Hydroxyethyl)imidazole

: 152567-69-6
2-[3-(2-Imidazol-1-yl-ethyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / SOBr₂ / CH₂Cl₂ / 1 h / Ambient temperature

2: 76 percent / K₂CO₃ / dimethylformamide / 5 h / 80 °C

With sulfurous dibromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00077a008

Reference yield:

: 529-19-1
2-Methylbenzonitrile

: 152567-69-6
2-[3-(2-Imidazol-1-yl-ethyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi, 3.) aq. HCl

2: 83 percent / pyridine, KMnO₄ / H₂O / 2 h / Heating

3: 66 percent / 80percent N₂H₄*H₂O / ethanol / 3 h / Heating

4: 61 percent / conc. H₂SO₄ / 12 h / Heating

5: 76 percent / K₂CO₃ / dimethylformamide / 5 h / 80 °C

With pyridine; hydrogenchloride; potassium permanganate; n-butyllithium; sulfuric acid; potassium carbonate; hydrazine hydrate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00077a008