7-((oxiran-2-yl)methoxy)-6-(4-benzhydrylpiperazin-1-yl)-2-bromo-7-methyl-7H-indeno[2,1-c]quinoline

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Chemical Name:7-((oxiran-2-yl)methoxy)-6-(4-benzhydrylpiperazin-1-yl)-2-bromo-7-methyl-7H-indeno[2,1-c]quinoline
CAS No.:1431544-36-3
Molecular Formula:C₃₇H₃₄BrN₃O₂
Molecular Weight:632.6
Hs Code.:

Synonyms:7-((oxiran-2-yl)methoxy)-6-(4-benzhydrylpiperazin-1-yl)-2-bromo-7-methyl-7H-indeno[2,1-c]quinoline

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Chemical Property of 7-((oxiran-2-yl)methoxy)-6-(4-benzhydrylpiperazin-1-yl)-2-bromo-7-methyl-7H-indeno[2,1-c]quinoline

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Technology Process of 7-((oxiran-2-yl)methoxy)-6-(4-benzhydrylpiperazin-1-yl)-2-bromo-7-methyl-7H-indeno[2,1-c]quinoline

There total 4 articles about 7-((oxiran-2-yl)methoxy)-6-(4-benzhydrylpiperazin-1-yl)-2-bromo-7-methyl-7H-indeno[2,1-c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1431544-35-2
6-(4-benzhydrylpiperazin-1-yl)-2-bromo-7-methyl-7H-indeno[2,1-c]quinolin-7-ol

: 106-89-8,24969-06-0,13403-37-7
epichlorohydrin

: 1431544-36-3
7-((oxiran-2-yl)methoxy)-6-(4-benzhydrylpiperazin-1-yl)-2-bromo-7-methyl-7H-indeno[2,1-c]quinoline

Guidance literature:: 6-(4-benzhydrylpiperazin-1-yl)-2-bromo-7-methyl-7H-indeno[2,1-c]quinolin-7-ol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

epichlorohydrin; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.02.054

Reference yield:

: 841-77-0
diphenylmethylpiperazine

: 1431544-36-3
7-((oxiran-2-yl)methoxy)-6-(4-benzhydrylpiperazin-1-yl)-2-bromo-7-methyl-7H-indeno[2,1-c]quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 8 h / Reflux

2.1: tetrahydrofuran; diethyl ether / 5 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

3.2: 12 h / 20 °C / Inert atmosphere

With pyridine; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; 2.1: |Grignard Reaction;
DOI:10.1016/j.bmcl.2013.02.054

Reference yield:

: 1173292-31-3
2-bromo-6-chloro-indeno[2,1-c]quinolin-7-one

: 1431544-36-3
7-((oxiran-2-yl)methoxy)-6-(4-benzhydrylpiperazin-1-yl)-2-bromo-7-methyl-7H-indeno[2,1-c]quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 8 h / Reflux

2.1: tetrahydrofuran; diethyl ether / 5 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

3.2: 12 h / 20 °C / Inert atmosphere

With pyridine; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; 2.1: |Grignard Reaction;
DOI:10.1016/j.bmcl.2013.02.054