4-methyl-N'-(2-trideuteromethylbenzylidene)benzenesulfonohydrazide

Base Information

• Chemical Name: 4-methyl-N'-(2-trideuteromethylbenzylidene)benzenesulfonohydrazide
• CAS No.: 105930-63-0
• Molecular Formula: C₁₅H₁₆N₂O₂S
• Molecular Weight: 291.346
• Mol file: 105930-63-0.mol

Synonyms:4-methyl-N'-(2-trideuteromethylbenzylidene)benzenesulfonohydrazide

Chemical Property of 4-methyl-N'-(2-trideuteromethylbenzylidene)benzenesulfonohydrazide

Chemical Property:

Purity/Quality:

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Technology Process of 4-methyl-N'-(2-trideuteromethylbenzylidene)benzenesulfonohydrazide

There total 2 articles about 4-methyl-N'-(2-trideuteromethylbenzylidene)benzenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

o-(trideuteriomethyl)benzaldehyde (77765-22-1) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 4-methyl-N'-(2-trideuteromethylbenzylidene)benzenesulfonohydrazide (105930-63-0)

Guidance literature:

In ethanol; at 60 ℃; for 5h;

DOI:10.1002/chem.202102010

Reference yield:

ortho-bromobenzaldehyde (6630-33-7) → 4-methyl-N'-(2-trideuteromethylbenzylidene)benzenesulfonohydrazide (105930-63-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) morpholine, n-BuLi, 2) n-BuLi / 1) THF, hexane, -41 deg C, 2) THF, hexane, -78 deg C, 3) THF, hexane, -78 deg C, 1 h

2: 51 percent

With morpholine; n-butyllithium;

DOI:10.1021/ja00237a008

Reference yield: 80.0%

4-methyl-N'-(2-trideuteromethylbenzylidene)benzenesulfonohydrazide (105930-63-0) → 4-methyl-N'-(2-trideuteromethylbenzylidene)benzenesulfonohydrazide sodium salt

Guidance literature:

With sodium hydride; In dichloromethane; mineral oil; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/chem.202102010

upstream raw materials:

o-(trideuteriomethyl)benzaldehyde

toluene-4-sulfonic acid hydrazide

ortho-bromobenzaldehyde