1-((1H-tetrazol-5-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

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Chemical Name:1-((1H-tetrazol-5-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one
CAS No.:1417527-01-5
Molecular Formula:C₁₆H₁₅FN₆OS
Molecular Weight:358.399
Hs Code.:

Synonyms:1-((1H-tetrazol-5-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

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Chemical Property of 1-((1H-tetrazol-5-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

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Technology Process of 1-((1H-tetrazol-5-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

There total 7 articles about 1-((1H-tetrazol-5-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1417526-10-3
2-(2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetonitrile

: 1417527-01-5
1-((1H-tetrazol-5-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 90 - 100 ℃; for 2h;

Reference yield:

: 459-46-1
4-Fluorobenzyl bromide

: 1417527-01-5
1-((1H-tetrazol-5-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate; potassium iodide / acetone / 2 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Inert atmosphere; Reflux

3.1: water; lithium hydroxide monohydrate / isopropyl alcohol / 2 h / 20 °C

4.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 0.5 h / Cooling with ice

4.2: 0.17 h / Cooling with ice

5.1: trifluoroacetic anhydride / tetrahydrofuran / 0.17 h / -15 °C / Inert atmosphere

6.1: ammonium chloride; sodium azide / N,N-dimethyl-formamide / 2 h / 90 - 100 °C

With thionyl chloride; sodium azide; lithium hydroxide monohydrate; water; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone;

Reference yield:

: 35563-27-0
2-sulfanylidene-1,2,3,4,6,7-hexahydro-5H-cyclopenta[d]pyrimidin-4-one

: 1417527-01-5
1-((1H-tetrazol-5-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate; potassium iodide / acetone / 2 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Inert atmosphere; Reflux

3.1: water; lithium hydroxide monohydrate / isopropyl alcohol / 2 h / 20 °C

4.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 0.5 h / Cooling with ice

4.2: 0.17 h / Cooling with ice

5.1: trifluoroacetic anhydride / tetrahydrofuran / 0.17 h / -15 °C / Inert atmosphere

6.1: ammonium chloride; sodium azide / N,N-dimethyl-formamide / 2 h / 90 - 100 °C

With thionyl chloride; sodium azide; lithium hydroxide monohydrate; water; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone;