(S)-2-Amino-3-phenyl-propionic acid 2-ethyldisulfanyl-phenyl ester

Base Information

• Chemical Name: (S)-2-Amino-3-phenyl-propionic acid 2-ethyldisulfanyl-phenyl ester
• CAS No.: 714229-34-2
• Molecular Formula: C₁₇H₁₉NO₂S₂
• Molecular Weight: 333.475
• Mol file: 714229-34-2.mol

Synonyms:(S)-2-Amino-3-phenyl-propionic acid 2-ethyldisulfanyl-phenyl ester

Chemical Property of (S)-2-Amino-3-phenyl-propionic acid 2-ethyldisulfanyl-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Amino-3-phenyl-propionic acid 2-ethyldisulfanyl-phenyl ester

There total 3 articles about (S)-2-Amino-3-phenyl-propionic acid 2-ethyldisulfanyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-ethyldisulfanyl-phenyl ester (714229-47-7) → (S)-2-Amino-3-phenyl-propionic acid 2-ethyldisulfanyl-phenyl ester (714229-34-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1.5h;

DOI:10.1021/ja0491836

Reference yield:

2,2'-dithiobisphenol (6300-58-9) → (S)-2-Amino-3-phenyl-propionic acid 2-ethyldisulfanyl-phenyl ester (714229-34-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / BF₃*OEt₂ / CH₂Cl₂ / 3 h / 20 °C

2: 100 percent / EDCI; DMAP / CH₂Cl₂; tetrahydrofuran / 18 h / 20 °C

3: 94 percent / HCl / dioxane / 1.5 h / 20 °C

With hydrogenchloride; dmap; boron trifluoride diethyl etherate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

DOI:10.1021/ja0491836

Reference yield:

o-SSEt-phenol (714229-46-6) → (S)-2-Amino-3-phenyl-propionic acid 2-ethyldisulfanyl-phenyl ester (714229-34-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / EDCI; DMAP / CH₂Cl₂; tetrahydrofuran / 18 h / 20 °C

2: 94 percent / HCl / dioxane / 1.5 h / 20 °C

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

DOI:10.1021/ja0491836

upstream raw materials:

2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-ethyldisulfanyl-phenyl ester

2,2'-dithiobisphenol

o-SSEt-phenol

Downstream raw materials:

(S)-2-[2-((S)-2-{(S)-2-[2-((R)-2-Amino-3-tert-butyldisulfanyl-propionylamino)-acetylamino]-propionylamino}-5-guanidino-pentanoylamino)-acetylamino]-3-phenyl-propionic acid 2-ethyldisulfanyl-phenyl ester

N-[3-((2S,8S,11R,17S)-8-Benzyl-11-mercaptomethyl-17-methyl-3,6,9,12,15,18-hexaoxo-1,4,7,10,13,16-hexaaza-cyclooctadec-2-yl)-propyl]-guanidine