Technology Process of (+/-)-9-<(1'R,2'R,3'S)-2',3'-dihydroxycyclohexanyl>adenine
There total 13 articles about (+/-)-9-<(1'R,2'R,3'S)-2',3'-dihydroxycyclohexanyl>adenine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
under 2585.7 Torr;
DOI:10.1021/jo00048a018
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 35 percent / <(i-PrO)3P>4Pd / tetrahydrofuran; dimethylsulfoxide; hexane / 1) 0 deg C, 3 h, 2) rt, 24 h
2: 95 percent / 4-methylmorpholine N-oxide, OsO4 / acetone; H2O / 72 h
3: 85 percent / 70percent aq, HClO4 / acetone / 2 h
4: 88 percent / molecular sieves (3A) / dioxane / 16 h / Heating
5: 90 percent / Et2NSF3, N,N-dimethylaminopyridine / CH2Cl2 / -78 deg C to rt
6: 30percent aq. NH4OH / methanol
7: 10percent aq. HCl
8: 95 percent / H2 / 10percent Pd/C / methanol / 2585.7 Torr
With
hydrogenchloride; dmap; ammonium hydroxide; osmium(VIII) oxide; perchloric acid; diethylamino-sulfur trifluoride; 3 A molecular sieve; hydrogen; 4-methylmorpholine N-oxide;
palladium on activated charcoal; C36H84O12P4Pd;
In
tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; dimethyl sulfoxide; acetone;
DOI:10.1021/jo00048a018
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 3 h / 0 °C
2: 35 percent / <(i-PrO)3P>4Pd / tetrahydrofuran; dimethylsulfoxide; hexane / 1) 0 deg C, 3 h, 2) rt, 24 h
3: 95 percent / 4-methylmorpholine N-oxide, OsO4 / acetone; H2O / 72 h
4: 85 percent / 70percent aq, HClO4 / acetone / 2 h
5: 88 percent / molecular sieves (3A) / dioxane / 16 h / Heating
6: 90 percent / Et2NSF3, N,N-dimethylaminopyridine / CH2Cl2 / -78 deg C to rt
7: 30percent aq. NH4OH / methanol
8: 10percent aq. HCl
9: 95 percent / H2 / 10percent Pd/C / methanol / 2585.7 Torr
With
hydrogenchloride; dmap; ammonium hydroxide; osmium(VIII) oxide; perchloric acid; diethylamino-sulfur trifluoride; 3 A molecular sieve; hydrogen; 4-methylmorpholine N-oxide; 3-chloro-benzenecarboperoxoic acid;
palladium on activated charcoal; C36H84O12P4Pd;
In
tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; dimethyl sulfoxide; acetone;
DOI:10.1021/jo00048a018
