rel-(2R,3R,4S)-trans-6-(m-iodo-p-methoxyphenyl)-3-(methoxymethoxy)-4-methyl-5-hexen-2-ol

Base Information

Chemical Name:rel-(2R,3R,4S)-trans-6-(m-iodo-p-methoxyphenyl)-3-(methoxymethoxy)-4-methyl-5-hexen-2-ol
CAS No.:143191-45-1
Molecular Formula:C₁₆H₂₃IO₄
Molecular Weight:406.261
Hs Code.:

Synonyms:rel-(2R,3R,4S)-trans-6-(m-iodo-p-methoxyphenyl)-3-(methoxymethoxy)-4-methyl-5-hexen-2-ol

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Chemical Property of rel-(2R,3R,4S)-trans-6-(m-iodo-p-methoxyphenyl)-3-(methoxymethoxy)-4-methyl-5-hexen-2-ol

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Technology Process of rel-(2R,3R,4S)-trans-6-(m-iodo-p-methoxyphenyl)-3-(methoxymethoxy)-4-methyl-5-hexen-2-ol

There total 5 articles about rel-(2R,3R,4S)-trans-6-(m-iodo-p-methoxyphenyl)-3-(methoxymethoxy)-4-methyl-5-hexen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83569-29-3
cis,cis-2-methyl-3-hydroxy-4-(iodomethyl)-γ-butyrolactone

: 143191-45-1
rel-(2R,3R,4S)-trans-6-(m-iodo-p-methoxyphenyl)-3-(methoxymethoxy)-4-methyl-5-hexen-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / n-Bu₃SnH, AIBN / a) benzene, reflux, 6 h, b) benzene, CCl₄, 12 h

2: 94 percent / diisopropylethylamine / CH₂Cl₂ / 72 h / Ambient temperature

3: 81 percent / diisobutylaluminum hydride / toluene / 0.17 h / -78 °C

4: 1) lithium diisopropylamide / 1) THF, -75 deg C, 45 min, 2) THF, a) -80 deg C, 30 min, b) to room temperature

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In dichloromethane; toluene;
DOI:10.1021/jo00047a020

Reference yield:

: 116696-37-8
rel-(3S,4R,5S)-dihydro-4-hydroxy-3,5-dimethyl-2(3H)-furanone

: 143191-45-1
rel-(2R,3R,4S)-trans-6-(m-iodo-p-methoxyphenyl)-3-(methoxymethoxy)-4-methyl-5-hexen-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / diisopropylethylamine / CH₂Cl₂ / 72 h / Ambient temperature

2: 81 percent / diisobutylaluminum hydride / toluene / 0.17 h / -78 °C

3: 1) lithium diisopropylamide / 1) THF, -75 deg C, 45 min, 2) THF, a) -80 deg C, 30 min, b) to room temperature

With diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In dichloromethane; toluene;
DOI:10.1021/jo00047a020

Reference yield:

: 143191-34-8
rel-(3S,4R,5S)-dihydro-4-(methoxymethoxy)-3,5-dimethyl-2(3H)-furanone

: 143191-45-1
rel-(2R,3R,4S)-trans-6-(m-iodo-p-methoxyphenyl)-3-(methoxymethoxy)-4-methyl-5-hexen-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / diisobutylaluminum hydride / toluene / 0.17 h / -78 °C

2: 1) lithium diisopropylamide / 1) THF, -75 deg C, 45 min, 2) THF, a) -80 deg C, 30 min, b) to room temperature

With diisobutylaluminium hydride; lithium diisopropyl amide; In toluene;
DOI:10.1021/jo00047a020