(2S)-2-benzyloxycarbonylamino-succinic acid-4-methyl ester 1-(3-methyl-but-3-enyl)ester

Base Information

Chemical Name:(2S)-2-benzyloxycarbonylamino-succinic acid-4-methyl ester 1-(3-methyl-but-3-enyl)ester
CAS No.:199921-24-9
Molecular Formula:C₁₈H₂₃NO₆
Molecular Weight:349.384
Hs Code.:

Synonyms:(2S)-2-benzyloxycarbonylamino-succinic acid-4-methyl ester 1-(3-methyl-but-3-enyl)ester

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Chemical Property of (2S)-2-benzyloxycarbonylamino-succinic acid-4-methyl ester 1-(3-methyl-but-3-enyl)ester

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Technology Process of (2S)-2-benzyloxycarbonylamino-succinic acid-4-methyl ester 1-(3-methyl-but-3-enyl)ester

There total 3 articles about (2S)-2-benzyloxycarbonylamino-succinic acid-4-methyl ester 1-(3-methyl-but-3-enyl)ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 763-32-6
2-methyl-1-buten-4-ol

: 3160-47-2
N-(benzyloxycarbonyl)-L-aspartic acid 4-methyl ester

: 199921-24-9
(2S)-2-benzyloxycarbonylamino-succinic acid-4-methyl ester 1-(3-methyl-but-3-enyl)ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 22 ℃; for 12h;
DOI:10.1016/S0040-4020(97)01038-7

Reference yield:

: 35909-93-4
dimethyl (2S)-2-[(phenylmethoxy)carbonylamino]-butane-1,4-dioate

: 199921-24-9
(2S)-2-benzyloxycarbonylamino-succinic acid-4-methyl ester 1-(3-methyl-but-3-enyl)ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / aq. LiOH / tetrahydrofuran / 2 h / 0 °C

2: 71 percent / dicyclohexylcarbodiimide; dimethylaminopyridine / CH₂Cl₂ / 12 h / 0 - 22 °C

With dmap; lithium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; 1: Hydrolysis / 2: Esterification;
DOI:10.1016/S0040-4020(97)01038-7

Reference yield:

: 1152-61-0
N-Cbz-L-Asp

: 199921-24-9
(2S)-2-benzyloxycarbonylamino-succinic acid-4-methyl ester 1-(3-methyl-but-3-enyl)ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / KHCO₃ / dimethylformamide / 12 h / 22 °C

2: 91 percent / aq. LiOH / tetrahydrofuran / 2 h / 0 °C

3: 71 percent / dicyclohexylcarbodiimide; dimethylaminopyridine / CH₂Cl₂ / 12 h / 0 - 22 °C

With dmap; lithium hydroxide; potassium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Esterification / 2: Hydrolysis / 3: Esterification;
DOI:10.1016/S0040-4020(97)01038-7