(Z)-3-(5-fluoro-1-(4-isopropylbenzylidene)-2-methyl-1H-inden-3-yl)propanenitrile

Base Information

Chemical Name:(Z)-3-(5-fluoro-1-(4-isopropylbenzylidene)-2-methyl-1H-inden-3-yl)propanenitrile
CAS No.:1346513-16-3
Molecular Formula:C₂₃H₂₂FN
Molecular Weight:331.433
Hs Code.:

Synonyms:(Z)-3-(5-fluoro-1-(4-isopropylbenzylidene)-2-methyl-1H-inden-3-yl)propanenitrile

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Chemical Property of (Z)-3-(5-fluoro-1-(4-isopropylbenzylidene)-2-methyl-1H-inden-3-yl)propanenitrile

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Technology Process of (Z)-3-(5-fluoro-1-(4-isopropylbenzylidene)-2-methyl-1H-inden-3-yl)propanenitrile

There total 7 articles about (Z)-3-(5-fluoro-1-(4-isopropylbenzylidene)-2-methyl-1H-inden-3-yl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 54215-59-7
3-(5-fluoro-2-methyl-1H-inden-3-yl)propanenitrile

: 122-03-2
(4-isopropylbenzaldehyde)

: 1346513-16-3
(Z)-3-(5-fluoro-1-(4-isopropylbenzylidene)-2-methyl-1H-inden-3-yl)propanenitrile

Guidance literature:: 3-(5-fluoro-2-methyl-1H-inden-3-yl)propanenitrile; With sodium methylate; In methanol; at 20 ℃; for 0.5h;

(4-isopropylbenzaldehyde); In methanol; at 80 ℃; for 4h;

With hydrogenchloride; In water; at 20 ℃; for 0.5h; pH=4 - 6;
DOI:10.1016/j.ejmech.2013.01.012

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1346513-16-3
(Z)-3-(5-fluoro-1-(4-isopropylbenzylidene)-2-methyl-1H-inden-3-yl)propanenitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / 0.08 h / 0 °C

1.2: 12 h / 160 - 180 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 7600.51 Torr

3.1: polyphosphoric acid / 12 h / 80 °C

4.1: isopropyl alcohol / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

4.2: 0.08 h / 0 °C / Inert atmosphere

5.1: acetic acid; sulfuric acid / 4 h / 20 °C

6.1: sodium methylate / methanol / 0.5 h / 20 °C

6.2: 4 h / 80 °C

6.3: 0.5 h / 20 °C / pH 4 - 6

With sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium methylate; potassium carbonate; acetic acid; isopropyl alcohol; In tetrahydrofuran; methanol; 1.1: |Perkin Carboxylic Acid Synthesis / 1.2: |Perkin Carboxylic Acid Synthesis / 3.1: |Friedel-Crafts Acylation / 6.1: |Claisen-Schmidt Condensation / 6.2: |Claisen-Schmidt Condensation;
DOI:10.1016/j.ejmech.2013.01.012

Reference yield:

: 22138-72-3
3-(4-fluorophenyl)-2-methylacrylic acid

: 1346513-16-3
(Z)-3-(5-fluoro-1-(4-isopropylbenzylidene)-2-methyl-1H-inden-3-yl)propanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 7600.51 Torr

2.1: polyphosphoric acid / 12 h / 80 °C

3.1: isopropyl alcohol / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

3.2: 0.08 h / 0 °C / Inert atmosphere

4.1: acetic acid; sulfuric acid / 4 h / 20 °C

5.1: sodium methylate / methanol / 0.5 h / 20 °C

5.2: 4 h / 80 °C

5.3: 0.5 h / 20 °C / pH 4 - 6

With sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium methylate; acetic acid; isopropyl alcohol; In tetrahydrofuran; methanol; 2.1: |Friedel-Crafts Acylation / 5.1: |Claisen-Schmidt Condensation / 5.2: |Claisen-Schmidt Condensation;
DOI:10.1016/j.ejmech.2013.01.012